Torra M, Rodamilans M, Montero F, Corbella J
Toxicology Unit, Hospital Clinic i Provincial, Facultat de Medicina, Universitat de Barcelona, Spain.
Biol Trace Elem Res. 1997 Jul-Aug;58(1-2):127-33. doi: 10.1007/BF02910673.
Selenium (Se) is an essential element, cofactor for glutathione peroxidase (GSHPx) activity, whose deficiency may induce modifications in the cellular antioxidative status and induce the appearance of different diseases. Current views suggest that a serum Se concentration inferior to 45 micrograms/L may correlate with an increased risk of coronary hearth diseases, coronary atherosclerosis and cancer. Since the Se concentration in human blood varies between geographical areas, we initiated a study to evaluate the Se status in the general healthy population of Barcelona. Serum Se concentration was investigated in a random sample of 150 subjects (age range 18-70 yr) by graphite furnace atomic spectrometry (FLAAS). L'vov platform, Zeeman background correction, and other specifications of stabilized temperature platform furnace (STPF) concept were followed. The results show that in the general population of Barcelona, Se serum concentration ranges between 60 and 106 micrograms/L (X = 80.7 +/- 10 micrograms/L). These values can be considered within the safe limits, since no subject was found with a concentration lower than the threshold of 45 micrograms/L.
硒（Se）是一种必需元素，是谷胱甘肽过氧化物酶（GSHPx）活性的辅助因子，其缺乏可能会引起细胞抗氧化状态的改变，并引发各种疾病。目前的观点认为，血清硒浓度低于45微克/升可能与冠心病、冠状动脉粥样硬化和癌症风险增加相关。由于人类血液中的硒浓度因地理区域而异，我们开展了一项研究来评估巴塞罗那普通健康人群的硒状态。通过石墨炉原子光谱法（FLAAS）对150名受试者（年龄范围18 - 70岁）的随机样本进行血清硒浓度检测。遵循了L'vov平台、塞曼背景校正以及稳定温度平台炉（STPF）概念的其他规范。结果显示，在巴塞罗那的普通人群中，血清硒浓度范围在60至106微克/升之间（X = 80.7 +/- 10微克/升）。这些值可被认为在安全范围内，因为未发现有受试者的浓度低于45微克/升的阈值。
