Matsuoka H, Shibata E, Ikezaki A, Kim H S, Yamazaki K, Murata M
Department of Pediatrics, Tokyo Women's Medical College Daini Hospital, Japan.
Acta Paediatr Jpn. 1997 Oct;39(5):628-30. doi: 10.1111/j.1442-200x.1997.tb03655.x.
We report on a Japanese girl with Turner syndrome (45,XO) who developed ganglioneuroma of the left adrenal gland during growth hormone (GH) therapy. She had received GH replacement therapy from the age of 6.8 years. At the age of 10.3 years, abdominal ultrasonography revealed a mass which occupied the upper area of her left kidney. Computed tomography and magnetic resonance imaging of the abdomen showed a low density mass with a smooth surface located between the upper portion of the left renal vein and the pancreas. Microscopic examination resulted in a diagnosis of ganglioneuroma of the left adrenal gland. At present we cannot conclude that patients who have received GH replacement therapy are at higher risk for developing tumors compared to those without GH replacement therapy.
我们报告了一名患有特纳综合征（45,XO）的日本女孩，她在生长激素（GH）治疗期间发生了左肾上腺神经节瘤。她从6.8岁开始接受GH替代治疗。10.3岁时，腹部超声检查发现一个肿块占据左肾上部区域。腹部计算机断层扫描和磁共振成像显示，一个表面光滑的低密度肿块位于左肾静脉上部和胰腺之间。显微镜检查诊断为左肾上腺神经节瘤。目前，我们无法得出接受GH替代治疗的患者与未接受GH替代治疗的患者相比发生肿瘤的风险更高的结论。
