Kulin H E, Finkelstein J W, D'Arcangelo M R, Susman E J, Chinchilli V, Kunselman S, Schwab J, Demers L, Lookingbill G
Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey 17033, USA.
J Pediatr Endocrinol Metab. 1997 Jul-Aug;10(4):395-400. doi: 10.1515/jpem.1997.10.4.395.
In a group of 22 boys with constitutional delay in growth and/or adolescence, intermittent testosterone enanthate treatment was employed in a randomized clinical trial at multiple doses ranging from 25-100 mg every two weeks for three month periods extending over 15-21 months. Twelve of the patients displayed a prompt increase in endogenous testosterone levels during the study period, reaching levels in the adult male range (> 250 ng/dl). The remaining 10 boys showed sluggish changes in endogenous testosterone during the investigation, ranging from 35-177 ng/dl. The bone ages and testicular sizes of the two groups at study initiation did not differ though urine LH was significantly less at study entry in the slowly maturing group. The data reveal a great diversity in the pace and pattern of endogenous testosterone changes in the study population. The results also suggest that exogenous sex steroid treatment of such patients does not speed up the central nervous system processes controlling the onset and progression of puberty. Boys with delayed puberty should be followed until endogenous testosterone levels reach the adult male range in order to rule out mild gonadotropin deficits.
在一组22名生长和/或青春期体质性发育延迟的男孩中，采用了庚酸睾酮间歇治疗进行随机临床试验，每两周使用25 - 100毫克的多剂量方案，为期三个月，持续15 - 21个月。在研究期间，12名患者的内源性睾酮水平迅速升高，达到成年男性范围（> 250 ng/dl）。其余10名男孩在研究期间内源性睾酮变化缓慢，范围为35 - 177 ng/dl。两组在研究开始时的骨龄和睾丸大小没有差异，尽管在研究开始时，发育缓慢组的尿促黄体生成素明显较低。数据显示，研究人群内源性睾酮变化的速度和模式存在很大差异。结果还表明，对此类患者进行外源性性类固醇治疗并不能加速控制青春期开始和进展的中枢神经系统进程。青春期延迟的男孩应进行随访，直到内源性睾酮水平达到成年男性范围，以排除轻度促性腺激素缺乏。
