Bergadá I, Bergadá C
Hospital de Niños R. Gutierrez, Division of Endocrinology, Buenos Aires, Argentina.
J Pediatr Endocrinol Metab. 1995 Apr-Jun;8(2):117-22. doi: 10.1515/jpem.1995.8.2.117.
We compared the effects of long term low dose treatment with testosterone on pubertal growth and sexual development in boys with constitutional delay of growth and puberty (CDGP). We treated 24 boys with intramuscular monthly injections with low dose testosterone enanthate (33-50 mg) for 20 months, at a chronological age of 14.5 +/- 1.0 years and SDS height of -3.31 and compared their response to a group of 14 control boys. Treated patients showed an earlier and significant increase in height velocity compared to controls, 10.1 vs 4.0 cm/year, while the latter group showed their growth spurt twelve months later. Both groups showed an initial acceleration in bone age without impairment of predicted adult height. During the first 12 months of treatment the increment of testicular volume in the treated patients was slightly slower than controls; however the earlier the puberty, the slower the testicular increment compared to controls. We conclude that treatment of boys with constitutional delay of growth with low dose testosterone is effective in improving their height velocity without impairment of predicted final height. Progression of testicular volume during treatment in some patients is more delayed; however, after treatment it increased normally.
我们比较了长期低剂量睾酮治疗对体质性生长和青春期延迟（CDGP）男孩青春期生长和性发育的影响。我们对24名男孩进行治疗，在其实际年龄14.5±1.0岁、身高标准差分数为-3.31时，每月肌肉注射低剂量庚酸睾酮（33 - 50毫克），持续20个月，并将他们的反应与14名对照男孩组成的一组进行比较。与对照组相比，接受治疗的患者身高增长速度更早且显著加快，分别为10.1厘米/年和4.0厘米/年，而后一组在12个月后才出现生长突增。两组患者的骨龄起初均有加速，且预测成年身高未受影响。在治疗的前12个月，接受治疗患者的睾丸体积增加略慢于对照组；然而，青春期开始越早，与对照组相比睾丸体积增加越慢。我们得出结论，用低剂量睾酮治疗体质性生长延迟的男孩可有效提高其身高增长速度，且不影响预测的最终身高。部分患者在治疗期间睾丸体积的进展更为延迟；不过，治疗后其正常增加。
