Haggarty P, Page K, Abramovich D R, Ashton J, Brown D
Rowett Research Institute, Aberdeen, UK.
Placenta. 1997 Nov;18(8):635-42. doi: 10.1016/s0143-4004(97)90004-7.
The role of the placenta in controlling the supply of fatty acids to the fetus was investigated in term placentae (n = 9) from normal pregnancies. The maternal side was perfused ex vivo for 90 min with a modified Krebs Ringer solution containing a physiological mixture of fatty acids and ratio of fatty acid to human albumin. There was no evidence of chain elongation and desaturation of the essential fatty acids. Relative to the value for oleic acid, the rate of transfer to the fetal circulation was: 1.30 +/- 0.02 (P < 0.001) for linoleic acid, 1.61 +/- 0.09 (P = 0.002) for alpha-linolenic acid, 0.67 +/- 0.10 (P = 0.033) for arachidonic acid and 2.10 +/- 0.16 (P = 0.003) for docosahexaenoic acid. For tissue accumulation the values were 1.47 +/- 0.39 (P < 0.001) for linoleic acid, 2.24 +/- 0.37 (P = 0.027) for alpha-linolenic acid, 9.84 +/- 1.03 (P = 0.001) for arachidonic acid, and 3.01 +/- 0.79 (P = 0.064) for docosahexaenoic acid. The order of selectivity for transfer from the maternal to the fetal circulation was docosahexaenoic > alpha-linolenic > linoleic > oleic > arachidonic acid. Such a mechanism would allow the preferential transfer of docosahexaenoic acid and the essential fatty acids to the fetal circulation, thereby protecting the polyunsaturated fatty acid supply to the fetus during a critical period of development.
在正常妊娠足月胎盘（n = 9）中研究了胎盘在控制向胎儿供应脂肪酸方面的作用。将胎盘母体侧在体外灌注含脂肪酸生理混合物及脂肪酸与人白蛋白比例的改良 Krebs Ringer 溶液90分钟。没有证据表明必需脂肪酸有链延长和去饱和现象。相对于油酸的值，向胎儿循环的转运速率为：亚油酸为1.30±0.02（P<0.001），α-亚麻酸为1.61±0.09（P = 0.002），花生四烯酸为0.67±0.10（P = 0.033），二十二碳六烯酸为2.10±0.16（P = 0.003）。对于组织蓄积，亚油酸的值为1.47±0.39（P<0.001），α-亚麻酸为2.24±0.37（P = 0.027），花生四烯酸为9.84±1.03（P = 0.001），二十二碳六烯酸为3.01±0.79（P = 0.064）。从母体向胎儿循环转运的选择性顺序为二十二碳六烯酸>α-亚麻酸>亚油酸>油酸>花生四烯酸。这样一种机制将允许二十二碳六烯酸和必需脂肪酸优先转运至胎儿循环，从而在发育的关键时期保护向胎儿的多不饱和脂肪酸供应。
