四肢瘫痪的活动型和久坐型男性的脂质、脂蛋白和载脂蛋白谱。
Lipid, lipoprotein, and apolipoprotein profiles in active and sedentary men with tetraplegia.
作者信息
Dallmeijer A J, Hopman M T, van der Woude L H
机构信息
Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit Amsterdam, The Netherlands.
出版信息
Arch Phys Med Rehabil. 1997 Nov;78(11):1173-6. doi: 10.1016/s0003-9993(97)90327-0.
OBJECTIVE
To investigate whether the risk profile of coronary heart disease (CHD) is more favorable in physically active men with tetraplegia compared with sedentary men with tetraplegia.
DESIGN
Using a cross-sectional design, the lipid and (apo)lipoprotein concentrations of 11 active and 13 sedentary men with tetraplegia were compared. Regression analysis was applied to investigate the influence of subject characteristics and behavioral factors on the risk profile of CHD.
MAIN OUTCOME MEASURES
Total plasma cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein-A1 (ApoA1), and apolipoprotein-B (ApoB) concentrations were determined. Low-density lipoprotein cholesterol (LDL-C) and the ratios TC/HDL-C, LDL-C/HDL-C, ApoA1/ApoB, and HDL-C/ApoA1 were calculated.
RESULTS
A significantly higher HDL-C and ApoA1/ApoB and lower TC/HDL-C were found in the active group. Age and body mass index were important determinants of the lipids and (apo)lipoproteins. Sport activity was the only significant determinant of HDL-C.
CONCLUSIONS
Results suggest a positive influence of sport activity on HDL-C in men with tetraplegia, which may reduce the risk of CHD.
目的
研究与久坐的四肢瘫痪男性相比，积极运动的四肢瘫痪男性的冠心病（CHD）风险状况是否更有利。
设计
采用横断面设计，比较11名积极运动的四肢瘫痪男性和13名久坐的四肢瘫痪男性的脂质和（载脂蛋白）脂蛋白浓度。应用回归分析来研究受试者特征和行为因素对冠心病风险状况的影响。
主要观察指标
测定总血浆胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯、载脂蛋白A1（ApoA1）和载脂蛋白B（ApoB）浓度。计算低密度脂蛋白胆固醇（LDL-C）以及TC/HDL-C、LDL-C/HDL-C、ApoA1/ApoB和HDL-C/ApoA1比值。
结果
活跃组中HDL-C和ApoA1/ApoB显著更高，而TC/HDL-C更低。年龄和体重指数是脂质和（载脂蛋白）脂蛋白的重要决定因素。体育活动是HDL-C的唯一显著决定因素。
结论
结果表明体育活动对四肢瘫痪男性的HDL-C有积极影响，这可能降低冠心病风险。
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