Vichiansiri Ratana, Saengsuwan Jittima, Manimmanakorn Nuttaset, Patpiya Sirasaporn, Preeda Arayawichanon, Samerduen Kharmwan, Poosiripinyo Ekasit
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Khon Kaen University, Amphur Muang, Khon Kaen 40002, Thailand.
Cholesterol. 2012;2012:847462. doi: 10.1155/2012/847462. Epub 2012 Jul 10.
Objective. To assess the prevalence of dyslipidemia in 90 patients with spinal cord lesion (SCL) of duration greater than 2 years. The study was carried out from November 2007 to September 2008. Methods. Clinical history, physical examination, and lipid profiles were recorded and analyzed. Dyslipidemia was assessed using guidelines from the National Cholesterol Education Project Adult Treatment Panel III (ATP III). Results. The prevalence of dyslipidemia in at least one lipid parameter was 76.7%. The most frequent finding was low HDL-C (58.9%). Hypertriglyceridemia, hypercholesterolemia and high LDL-C were found in 28.9%, 26.7% and 21.1% of patients, respectively. The factors sex = male and age ≥45 years were associated with high LDL-C (P < 0.05 and P < 0.01). Patients who exercised less than 30 minutes per day had associated hypercholesterolemia (P < 0.01), hypertriglyceridemia (P < 0.01), and higher LDL-C (P < 0.05). Patients with BMI ≥23 kg/m(2) had associated hypercholesterolemia and high LDL-C. Age was a significant determinant of high LDL-C. BMI was the most powerful and significant determinant of hypercholesterolemia and high LDL-C. Conclusion. SCL patients should have a regular lipid checkup, especially those patients having the following risk factors: males, age ≥45 years, BMI ≥23 kg/m(2) and exercise duration <30 minutes per day.
目的。评估90例病程超过2年的脊髓损伤（SCL）患者的血脂异常患病率。该研究于2007年11月至2008年9月进行。方法。记录并分析临床病史、体格检查和血脂谱。使用美国国家胆固醇教育计划成人治疗小组第三次报告（ATP III）的指南评估血脂异常。结果。至少一项血脂参数存在血脂异常的患病率为76.7%。最常见的发现是高密度脂蛋白胆固醇（HDL-C）降低（58.9%）。高甘油三酯血症、高胆固醇血症和低密度脂蛋白胆固醇（LDL-C）升高分别在28.9%、26.7%和21.1%的患者中发现。男性性别和年龄≥45岁与LDL-C升高相关（P < 0.05和P < 0.01）。每天锻炼少于30分钟的患者伴有高胆固醇血症（P < 0.01）、高甘油三酯血症（P < 0.01）和更高的LDL-C（P < 0.05）。体重指数（BMI）≥23 kg/m²的患者伴有高胆固醇血症和LDL-C升高。年龄是LDL-C升高的重要决定因素。BMI是高胆固醇血症和LDL-C升高最有力且显著的决定因素。结论。SCL患者应定期进行血脂检查，尤其是那些具有以下危险因素的患者：男性、年龄≥45岁、BMI≥23 kg/m²以及每天锻炼时间<30分钟。
