欧洲青少年的脂质、脂蛋白和载脂蛋白谱及其与性别、生物成熟度和体脂肪的关系——HELENA 研究。

Lipid, lipoprotein and apolipoprotein profiles in European adolescents and its associations with gender, biological maturity and body fat--the HELENA Study.

机构信息

Institut für Ernährungs- und Lebensmittelwissenschaften, Universität Bonn, Bonn, Germany.

出版信息

Eur J Clin Nutr. 2012 Jun;66(6):727-35. doi: 10.1038/ejcn.2011.222. Epub 2012 Jan 18.

DOI:10.1038/ejcn.2011.222

Abstract

BACKGROUND/OBJECTIVES: To provide a detailed lipid profile of a European adolescent population considering age, gender, biological maturity, body mass index (BMI), fat mass (FM) and percentage body fat (BF).

SUBJECTS/METHODS: Within Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA), a cross-sectional study was conducted to determine fasting serum concentrations of lipids, lipoproteins and apolipoproteins in 1076 adolescents aged 12.5-17.49 years from ten European centres.

RESULTS

All serum lipid concentrations were significantly higher in girls than in boys. In boys, age was negatively correlated with high-density lipoprotein (HDL)-cholesterol and total cholesterol (TC), and positively associated with triacylglycerides (TAG) (P < 0.01) whereas no significant associations were observed in girls. Biological maturity was negatively associated with TC, HDL-, low-density lipoprotein (LDL)- and non-HDL cholesterol in boys (all P<0.05) and negatively correlated with HDL-cholesterol in girls (P<0.05). BMI, FM and BF were significantly correlated with HDL-cholesterol, LDL-cholesterol, non-HDL cholesterol, apolipoprotein (apo) A1, apoB and TAG in both boys and girls.

CONCLUSIONS

The lipid profile in adolescents is strongly determined by gender. Biological maturity, FM and percentage BF contribute to the variance in lipid concentrations and should be considered in future evaluations of lipid status.

摘要

背景/目的：提供欧洲青少年人群的详细血脂谱，考虑年龄、性别、生物成熟度、体重指数（BMI）、脂肪量（FM）和体脂百分比（BF）。

受试者/方法：在欧洲青少年营养与生活方式（HELENA）的横断面研究中，对来自十个欧洲中心的 1076 名 12.5-17.49 岁青少年进行了空腹血清脂质、脂蛋白和载脂蛋白浓度的测定。

结果

所有血清脂质浓度在女孩中均显著高于男孩。在男孩中，年龄与高密度脂蛋白（HDL）-胆固醇和总胆固醇（TC）呈负相关，与三酰甘油（TAG）呈正相关（P<0.01），而在女孩中未观察到显著相关性。生物成熟度与男孩的 TC、HDL-、LDL-和非-HDL 胆固醇呈负相关（均 P<0.05），与女孩的 HDL-胆固醇呈负相关（P<0.05）。BMI、FM 和 BF 与男孩和女孩的 HDL-胆固醇、LDL-胆固醇、非-HDL 胆固醇、载脂蛋白（apo）A1、apoB 和 TAG 均呈显著相关。