Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas, United States.
Department of Physical Therapy, Jazan University, Jazan, Saudi Arabia.
J Spinal Cord Med. 2022 Jul;45(4):622-630. doi: 10.1080/10790268.2020.1853332. Epub 2021 Jan 14.
To investigate the effects of an 8-week walking training program on glycemic control, lipid profile, and inflammatory markers in individuals with chronic spinal cord injury (SCI).
A pilot, single-group, pretest-posttest study.
A neuromuscular research laboratory.
Eleven participants with chronic SCI.
An 8-week walking training program using a treadmill, a body weight-supported system, and an assistive gait training device.
Levels of glycated hemoglobin (HbA), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), C-reactive protein (CRP), and interleukin-6 were assessed before and after the walking training.
Following the walking training, there was a statistically significant decrease in HbA level (<0.01) of uncertain clinical significance. The lipid profile improved after training, as shown by a statistically and clinically significant increase in HDL-C level (<0.01) and a statistically significant decrease in LDL-C level (<0.1) of no clinical significance. The ratio of LDL-C to HDL-C was significantly reduced (<0.01). In regard to inflammatory markers, concentrations of IL-6 showed a significant reduction after training (=0.05) of unknown clinical significance, while those of CRP trended to decrease (=0.13).
The findings of this pilot study suggest that an 8-week walking training program may produce favorable changes in risk markers of cardiovascular disease in individuals with chronic SCI as shown by clinically meaningful improvements in HDL-C, and small changes in the right direction, but uncertain clinical significance, in HbA1c, LDL-C and IL-6. A randomized controlled trial is needed to compare the effects of walking training on these outcome measures with those of other exercise modalities suitable for this population, and to see if more prolonged exercise exposure leads to favorable parameters of significant size to justify the exercise modality.
探讨 8 周步行训练计划对慢性脊髓损伤（SCI）患者血糖控制、血脂谱和炎症标志物的影响。
单组、前后测试设计的初步研究。
神经肌肉研究实验室。
11 名慢性 SCI 患者。
使用跑步机、体重支撑系统和辅助步态训练设备进行 8 周步行训练计划。
在步行训练前后评估糖化血红蛋白（HbA）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、C 反应蛋白（CRP）和白细胞介素-6 的水平。
步行训练后，HbA 水平（<0.01）呈统计学意义显著下降，但临床意义不确定。训练后血脂谱改善，HDL-C 水平（<0.01）呈统计学和临床意义显著升高，LDL-C 水平（<0.1）呈统计学意义显著下降，但临床意义不确定。LDL-C/HDL-C 比值显著降低（<0.01）。关于炎症标志物，IL-6 浓度在训练后显著降低（=0.05），但临床意义不确定，CRP 浓度有下降趋势（=0.13）。
本初步研究结果表明，8 周步行训练计划可能对慢性 SCI 患者心血管疾病风险标志物产生有利变化，表现为 HDL-C 有临床意义的改善，HbA1c、LDL-C 和 IL-6 有小的但不确定的临床意义的改善。需要进行随机对照试验，比较步行训练对这些结局测量指标的影响与其他适合该人群的运动方式的影响，观察更长时间的运动暴露是否会导致有意义的参数有利于运动方式。
