Ishihara K, Ichikawa H, Takeuchi T, Kawamura M, Sugita K
Department of Neurology, Showa University School of Medicine.
Rinsho Shinkeigaku. 1997 Jun;37(6):509-13.
We describe a patient who presented with isolated retrograde amnesia of 2-year duration after recovery from viral encephalitis. The patient was a 29-year-old right-handed male dentist and was admitted to our hospital with a complaint of generalized convulsion. Cerebrospinal fluid (CSF) showed mononuclear pleocytosis. Neuroradiological examinations (X-ray CT, MRI and 123I-IMP SPECT) revealed no significant abnormality. Immunological method showed no specific increase of viral antibody titers. However, with a tentative diagnosis of viral encephalitis, administration of acyclovir was started. After 3 weeks he became comprehensive, and several kinds of neuropsychological tests were performed. His intelligence and immediate memory were normal, and his procedural memory of dentist was intact. On the other hand, he could not recall any information about events, both personal and public, occurred within 2 years before the onset of present illness. His autobiographical memory disorder was also demonstrated using a series of weekly comic. In isolated retrograde amnesia following viral encephalitis like this case, memory of relatively short time duration, acquired prior to the onset of present illness, tend to be disturbed.
我们描述了一名患者，他在病毒性脑炎康复后出现了持续2年的孤立性逆行性遗忘。该患者是一名29岁的右利手男性牙医，因全身性惊厥入院。脑脊液（CSF）显示单核细胞增多。神经放射学检查（X线CT、MRI和123I-IMP SPECT）未发现明显异常。免疫学方法显示病毒抗体滴度无特异性升高。然而，在初步诊断为病毒性脑炎后，开始给予阿昔洛韦治疗。3周后他恢复了意识，并进行了几种神经心理学测试。他的智力和即刻记忆正常，作为牙医的程序性记忆完好无损。另一方面，他无法回忆起任何关于发病前2年内发生的个人和公共事件的信息。使用一系列每周漫画也证明了他的自传体记忆障碍。在像该病例这样的病毒性脑炎后的孤立性逆行性遗忘中，发病前获得的相对较短时间的记忆往往会受到干扰。
