Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H
Clinical Research Center for Mental Health (CRC-MH), Antwerp, Belgium.
Cytokine. 1997 Nov;9(11):853-8. doi: 10.1006/cyto.1997.0238.
There is now some evidence that major depression is accompanied by an immune response with an increased production of pro-inflammatory cytokines, such as interleukin 1(IL-1), IL-6 and interferon gamma (IFN-gamma). The aims of the present study were to examine serum IL-6, IL-1 receptor antagonist (IL-1Ra), IL-6R, Clara cell protein (CC16) and the soluble CD8 (sCD8) molecule in chronic, treatment resistant depression (TRD) both before and after subchronic treatment with antidepressants. Serum IL-6 and IL-1Ra were significantly higher in subjects with major depression and TRD than in normal controls. Subchronic treatment with antidepressants had no significant effects on serum IL-6, IL-1Ra, CC16 or sCD8, but reduced serum sIL-6R levels significantly. There were significant and positive correlations between serum IL-6, on the one hand, and sIL-6R, IL-1Ra, sCD8, number of peripheral blood leukocytes, neutrophils, CD2(+)T and CD19(+)B cells (all positive) and serum zinc (negative), on the other. These results suggest that: (1) major depression and TRD are accompanied by an activation of the monocytic arm of cell-mediated immunity; (2) the latter may be related to the immune an acute phase response in major depression; and (3) the above disorders may persist despite successful antidepressive treatment.
目前有一些证据表明，重度抑郁症伴随着免疫反应，促炎细胞因子如白细胞介素1（IL-1）、IL-6和干扰素γ（IFN-γ）的产生增加。本研究的目的是在慢性难治性抑郁症（TRD）患者接受亚慢性抗抑郁药治疗前后，检测其血清IL-6、IL-1受体拮抗剂（IL-1Ra）、IL-6受体（IL-6R）、克拉拉细胞蛋白（CC16）和可溶性CD8（sCD8）分子水平。重度抑郁症和TRD患者的血清IL-6和IL-1Ra水平显著高于正常对照组。亚慢性抗抑郁药治疗对血清IL-6、IL-1Ra、CC16或sCD8无显著影响，但显著降低了血清可溶性IL-6受体（sIL-6R）水平。一方面，血清IL-6与sIL-6R、IL-1Ra、sCD8、外周血白细胞、中性粒细胞、CD2(+)T细胞和CD19(+)B细胞数量（均为正相关）以及血清锌（负相关）之间存在显著正相关。这些结果表明：（1）重度抑郁症和TRD伴随着细胞介导免疫的单核细胞分支的激活；（2）后者可能与重度抑郁症中的免疫急性期反应有关；（3）尽管抗抑郁治疗成功，上述紊乱可能仍然存在。
