Jaffe I A
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Neurol Clin. 1997 Nov;15(4):887-91. doi: 10.1016/s0733-8619(05)70353-4.
The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common mode of pathogenesis. The definitive diagnostic marker is histological, and that forms the best guide to specific therapy.
约25%的典型韦格纳肉芽肿患者神经系统受累。抗中性粒细胞胞浆抗体的发现拓宽了该疾病的范畴，这些抗体存在于许多具有共同临床特征的疾病中。抗中性粒细胞胞浆抗体检测可能提示一种共同的发病机制。确诊的诊断标志物是组织学检查，它是特异性治疗的最佳指导。
