Schull W J
U.T. Health Sciences Center, Medical Genetics Center, Houston, USA.
Stem Cells. 1997;15 Suppl 2:129-33. doi: 10.1002/stem.5530150719.
Mental retardation as a result of prenatal exposure to ionizing radiation is not a common phenomenon when compared to the incidence of cancer, but it has nevertheless been well-documented. This article describes results from studies of individuals who were exposed prenatally to radiation in Hiroshima and Nagasaki. The critical time of exposure, when the most significant damage was done, was during the 8th-15th week of gestation, with a lesser effect at 16-25 weeks. Individuals in the study were assessed by measurement of an intelligence quotient and by examination of school performance. Studies show that the period of 8-15 weeks of gestation coincides with a key time for neuronal cell migration in the developing brain. There is continuing investigation of the mechanism of this migration and how it might be disrupted by ionizing radiation.
与癌症的发病率相比，产前暴露于电离辐射导致智力迟钝并非常见现象，但已有充分的文献记载。本文描述了对广岛和长崎产前暴露于辐射的个体的研究结果。造成最严重损害的关键暴露时间是在妊娠第8至15周，16至25周时影响较小。研究中的个体通过智商测量和学业成绩检查进行评估。研究表明，妊娠8至15周与发育中大脑神经元细胞迁移的关键时期相吻合。目前正在持续研究这种迁移的机制以及电离辐射如何可能干扰它。
