Giagounidis A A, Meckenstock G, Flacke S, Burk M, Wehmeier A, Aul C, Schneider W
Clinic of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany.
Ann Hematol. 1997 Sep;75(3):121-3. doi: 10.1007/s002770050325.
Patients undergoing chemotherapy regimens for hematologic malignancies are prone to develop unusual and potentially life-threatening infections during periods of leukopenia- induced immunosuppression. We report the case of a woman who received consolidation chemotherapy for acute lymphocytic leukemia and acquired necrotizing Pseudomonas aeruginosa blepharoconjunctivitis of the right eye during a period of mild leukopenia. The infection led to severe orbital and periorbital inflammation, spreading down to the neck. High-dose antibiotic treatment with ceftazidime and tobramycin combined with granulocyte cell-stimulating factor cleared the infection after several days, but plastic surgery was needed to restore normal eye closure.
接受血液系统恶性肿瘤化疗方案的患者在白细胞减少所致免疫抑制期间容易发生异常且可能危及生命的感染。我们报告一例女性患者，她因急性淋巴细胞白血病接受巩固化疗，在轻度白细胞减少期间右眼发生了坏死性铜绿假单胞菌性睑结膜炎。感染导致严重的眼眶和眶周炎症，并蔓延至颈部。使用头孢他啶和妥布霉素进行高剂量抗生素治疗并联合粒细胞集落刺激因子，数天后感染得以清除，但需要进行整形手术来恢复正常的眼睑闭合。
