Giagounidis A A, Giagounidis A S, Germing U, Koch J A, Aul C
Klinik für Hämatologie, Onkologie und klinische Immunologie, Heinrich-Heine-Universität, Düsseldorf, Moorenstr. 5, D-40225 D usseldorf, Germany.
Eur J Med Res. 1999 Jan 26;4(1):27-30.
Pseudomonas aeruginosa orbital infections have been described very rarely in patients with neutropenia after chemotherapy. We report the case of a woman with the unusual association of Sjögren's disease and myelodysplasia, who suffered from a Pseudomonas aeruginosa orbital phlegmon after chemotherapy for her myelodysplastic syndrome. Partial intestinal antibiotic decontamination with ciprofloxacine did not prevent the infection. She was treated successfully with intravenous ceftazidime, netilmicin and granulocyte-colony stimulating factor (G-CSF). The normalization of the granulocyte count seems to play a crucial role for recovery. We present the clinical and radiological findings, discuss the therapy and review the literature concerning ocular infections due to Pseudomonas. Other infections due to this germ in immunocompromised hosts are briefly reviewed.
化疗后中性粒细胞减少的患者中，铜绿假单胞菌眼眶感染的报道极为罕见。我们报告了一例患有干燥综合征和骨髓增生异常综合征这一不寻常组合的女性病例，她在接受骨髓增生异常综合征化疗后患上了铜绿假单胞菌眼眶蜂窝织炎。用环丙沙星进行部分肠道抗生素去污并不能预防感染。她通过静脉注射头孢他啶、奈替米星和粒细胞集落刺激因子（G-CSF）得到了成功治疗。粒细胞计数的正常化似乎对康复起着关键作用。我们展示了临床和放射学检查结果，讨论了治疗方法，并回顾了有关铜绿假单胞菌引起的眼部感染的文献。还简要回顾了免疫功能低下宿主中由这种病菌引起的其他感染。
