Potolicchio I, Mosconi G, Forni A, Nemery B, Seghizzi P, Sorrentino R
Department of Cell Biology and Development, University of Rome La Sapienza, Italy.
Eur J Immunol. 1997 Oct;27(10):2741-3. doi: 10.1002/eji.1830271039.
Clinical, epidemiological and experimental data indicate that inhaled metal dust containing cobalt may produce an interstitial lung disease termed "hard metal disease" (HMD). Some aspects of this pathology such as the lack of correlation with dose exposure, the low frequency of the disease and the presence of T cells in the inflammation site, all suggest the existence of a genetic susceptibility, possibly to an immunological response to cobalt or to self proteins modified by cobalt. Here we report that HMD is strongly associated with residue Glu-69 of the HLA-DP beta chain. All patients, except for one with a rare genotype, possessed this marker as compared to 17 out of 35 exposed unaffected individuals (p = 0.0014). These data allow us to genetically distinguish a subgroup of cobalt-exposed individuals at risk for HMD, independently from the more common allergic reaction.
临床、流行病学和实验数据表明，吸入含钴金属粉尘可能会引发一种间质性肺病，称为“硬金属病”（HMD）。这种病理的某些方面，如与剂量暴露缺乏相关性、疾病发生率低以及炎症部位存在T细胞，都表明存在遗传易感性，可能是对钴或被钴修饰的自身蛋白质产生免疫反应。在此我们报告，HMD与HLA - DPβ链的Glu - 69残基密切相关。除一名具有罕见基因型的患者外，所有患者都具有这一标记，而在35名暴露但未患病的个体中，只有17人具有该标记（p = 0.0014）。这些数据使我们能够从基因上区分出有患HMD风险的钴暴露个体亚组，而与更常见的过敏反应无关。
