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T-cell signaling: the importance of receptor clustering.

作者信息

Germain R N

机构信息

Lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1892, USA.

出版信息

Curr Biol. 1997 Oct 1;7(10):R640-4. doi: 10.1016/s0960-9822(06)00323-x.

DOI:10.1016/s0960-9822(06)00323-x
PMID:9368747
Abstract

T-cell receptors bound to peptide-MHC molecules undergo higher-order oligomerization in solution. This observation, the low-affinity-recognition properties of T-cell receptors, and other indications that such receptors undergo rapid, serial engagement by a single ligand suggest a dynamic clustering model of T-cell signaling.

摘要

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