Magnaval J F, Galindo V, Glickman L T, Clanet M
Service de Parasitologie, CHU Purpan, Toulouse, France.
Parasitology. 1997 Nov;115 ( Pt 5):537-43. doi: 10.1017/s0031182097001558.
Infection with Toxocara canis is a common world-wide human helminthiasis, which rarely elicits central nervous system (CNS) impairment. A case-control study to investigate this discrepancy was carried out, in which the cases were 27 adult neurological inpatients for whom a definite aetiological diagnosis was lacking, and for whom positive immunodiagnosis of toxocariasis had been obtained, both in cerebrospinal fluid (CSF) and in serum. Two control groups were used. Controls were adult inpatients with other neurological diseases who had no evidence of T. canis infection of the CNS. Multivariate logistic regression analysis did not reveal any positive relation between case status and clinical signs. A significant association was observed between case status and an elevated CSF cell count. Rural residence, ownership of dogs, and dementia were shown to be risk factors for toxocaral infection of CNS. These results suggest that migration of T. canis larvae in the human brain does not frequently induce a recognizable neurological syndrome but is correlated with the association of several risk factors including exposure to dogs, a status possibly responsible for repeated low-dose infections.
犬弓首蛔虫感染是一种常见的全球性人体蠕虫病，很少引起中枢神经系统（CNS）损害。开展了一项病例对照研究以调查这种差异，其中病例为27名成年神经科住院患者，他们缺乏明确的病因诊断，但脑脊液（CSF）和血清中弓形虫病免疫诊断呈阳性。使用了两个对照组。对照组为患有其他神经系统疾病的成年住院患者，他们没有中枢神经系统犬弓首蛔虫感染的证据。多变量逻辑回归分析未发现病例状态与临床体征之间存在任何正相关关系。观察到病例状态与脑脊液细胞计数升高之间存在显著关联。农村居住、养狗和痴呆被证明是中枢神经系统弓形虫感染的危险因素。这些结果表明，犬弓首蛔虫幼虫在人脑中的移行并不常诱发可识别的神经综合征，但与包括接触狗在内的多种危险因素相关，这种状态可能导致反复低剂量感染。
