Daldrup H E, Schuierer G, Link T M, Moeller H, Bick U, Kurlemann G, Peters P E
Institute of Clinical Radiology, Westfälische Wilhelms Universität, D-48149 Münster, Germany.
Eur Radiol. 1997;7(9):1478-84. doi: 10.1007/s003300050320.
The aim of our work was to determine the efficacy of turbo inversion recovery spin echo (TIRSE) pulse sequences in differentiating patients with normal and abnormal myelination. Twenty neurological normal children (aged 5 months to 12 years) as well as 65 children presenting clinically with neurologic developmental deficits (aged 2 months to 10 years) were examined using TIRSE, T1-weighted SE, and T2-weighted turbo SE pulse sequences. Contrast-to-noise-ratio (CNR) between myelinated white and gray matter was compared for the different pulse sequences. In addition, two readers analyzed all images qualitatively by consensus. The CNR values were significantly higher on TIRSE images as compared with conventional images (p < 0. 05). Forty-two neurologically abnormal patients displayed a normal myelination on all sequences, whereas 23 showed an abnormal myelination. The TIRSE sequence provided a sensitive and specific depiction of an abnormal myelination in all of these patients. The TIRSE sequence provided additional information to conventional pulse sequences in determining myelination disorders in children, especially in children older than 2 years.
我们这项工作的目的是确定快速反转恢复自旋回波（TIRSE）脉冲序列在鉴别髓鞘形成正常和异常的患者方面的效能。使用TIRSE、T1加权自旋回波（SE）和T2加权快速SE脉冲序列对20名神经功能正常的儿童（年龄5个月至12岁）以及65名临床上表现为神经发育缺陷的儿童（年龄2个月至10岁）进行了检查。比较了不同脉冲序列下有髓白质和灰质之间的对比噪声比（CNR）。此外，两名阅片者通过达成共识对所有图像进行了定性分析。与传统图像相比，TIRSE图像上的CNR值显著更高（p<0.05）。42名神经功能异常的患者在所有序列上均显示髓鞘形成正常，而23名患者显示髓鞘形成异常。TIRSE序列对所有这些患者的异常髓鞘形成提供了敏感且特异的显示。TIRSE序列在确定儿童尤其是2岁以上儿童的髓鞘形成障碍方面为传统脉冲序列提供了额外信息。
