Dietrich R B, Bradley W G, Zaragoza E J, Otto R J, Taira R K, Wilson G H, Kangarloo H
Department of Radiological Sciences, UCLA School of Medicine, CA 90024.
AJR Am J Roentgenol. 1988 Apr;150(4):889-96. doi: 10.2214/ajr.150.4.889.
This study demonstrates the ability of MR imaging to show progression of myelination in 64 infants and young children (ages 4 days to 36 months). T2-weighted spin-echo pulse sequences, frequently used for routine screening of intracranial disease, were used. Gray-white matter differentiation was seen in all patients, and changes occurring with age were documented. Three distinct patterns were seen, and age ranges were established for each pattern in developmentally normal children: (1) infantile (birth-6 months); (2) isointense (8-12 months); and (3) early adult (10 months onward). There was a statistically significant difference between the age ranges of the normal and developmentally delayed children showing all three patterns. These data should be helpful for identifying and following sequentially both infants with clinically suspected developmental delay and those with dysmyelinating or demyelinating disease.
本研究证明了磁共振成像（MR）显示64例婴幼儿（年龄4天至36个月）髓鞘形成进展情况的能力。使用了常用于颅内疾病常规筛查的T2加权自旋回波脉冲序列。所有患者均可见灰白质分化，并记录了随年龄发生的变化。观察到三种不同模式，并为发育正常儿童的每种模式确定了年龄范围：（1）婴儿期（出生至6个月）；（2）等信号期（8至12个月）；（3）早期成人期（10个月及以后）。显示出所有三种模式的正常儿童和发育迟缓儿童的年龄范围之间存在统计学上的显著差异。这些数据应有助于识别和连续跟踪临床上疑似发育迟缓的婴儿以及患有脱髓鞘或髓鞘发育异常疾病的婴儿。
