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Adenosine A1 receptor agonists as clinically viable agents for treatment of ischemic brain disorders.腺苷A1受体激动剂作为治疗缺血性脑疾病的临床可行药物。
Ann N Y Acad Sci. 1997 Oct 15;825:23-9. doi: 10.1111/j.1749-6632.1997.tb48411.x.
2
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.腺苷、腺苷A1受体和ATP敏感性钾通道在脑缺血预处理中的重要作用。
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4666-70. doi: 10.1073/pnas.92.10.4666.
3
Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?腺苷与脑缺血：治疗前景还是一个大胆概念的终结？
Eur J Pharmacol. 1999 Jan 15;365(1):9-25. doi: 10.1016/s0014-2999(98)00788-2.
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Adenosine A2A receptors and neuroprotection.腺苷A2A受体与神经保护作用
Ann N Y Acad Sci. 1997 Oct 15;825:30-48. doi: 10.1111/j.1749-6632.1997.tb48412.x.
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Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?腺苷与脑缺血：治疗前景还是一个大胆概念的终结？
Eur J Pharmacol. 1999 Apr 23;371(1):85-102. doi: 10.1016/s0014-2999(99)00135-1.
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Brain adenosine receptors as targets for therapeutic intervention in neurodegenerative diseases.脑腺苷受体作为神经退行性疾病治疗干预的靶点。
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Adenosine A3 receptor stimulation and cerebral ischemia.腺苷A3受体刺激与脑缺血
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[Comparative characteristics of A1-receptor agonists as neuroprotective agents].
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Adenosine A1 receptor activation preferentially protects cultured cerebellar neurons versus astrocytes against hypoxia-induced death.与星形胶质细胞相比，腺苷A1受体激活可优先保护培养的小脑神经元免受缺氧诱导的死亡。
Mol Chem Neuropathol. 1997 Jun;31(2):119-33. doi: 10.1007/BF02815237.

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Activation of Adenosine A Receptor in Ischemic Stroke: Neuroprotection by Tetrahydroxy Stilbene Glycoside as an Agonist.缺血性卒中中腺苷A受体的激活：四羟基茋苷作为激动剂的神经保护作用
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Translating drug-induced hibernation to therapeutic hypothermia.将药物诱导的冬眠转化为治疗性低温。
ACS Chem Neurosci. 2015 Jun 17;6(6):899-904. doi: 10.1021/acschemneuro.5b00056. Epub 2015 Apr 8.
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Altered thermoregulation via sensitization of A1 adenosine receptors in dietary-restricted rats.饮食限制大鼠通过 A1 腺苷受体敏化作用改变体温调节。
Psychopharmacology (Berl). 2010 Apr;209(3):217-24. doi: 10.1007/s00213-010-1778-y. Epub 2010 Feb 26.
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Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade.腺苷对大脑的神经保护作用：从 A(1)受体激活到 A (2A)受体阻断。
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NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors.磷酸酶1/2A抑制剂可阻断N-甲基-D-天冬氨酸受体介导的细胞外腺苷积累。
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7
The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.腺苷A1受体激动剂胺基腺苷类似物在3-硝基丙酸神经毒性模型中，对纹状体损伤和运动障碍的发展具有神经保护作用。
J Neurosci. 2002 Oct 15;22(20):9122-33. doi: 10.1523/JNEUROSCI.22-20-09122.2002.
8
Seizure activity produces differential changes in adenosine A1 receptors within rat hippocampus.癫痫发作活动会使大鼠海马体内的腺苷A1受体产生不同变化。
Neurochem Res. 2001 Mar;26(3):225-30. doi: 10.1023/a:1010912516299.
9
Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice.大鼠海马切片CA1区缺氧时腺苷释放的直接测量。
J Physiol. 2000 Jul 1;526 Pt 1(Pt 1):143-55. doi: 10.1111/j.1469-7793.2000.00143.x.
10
Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist.腺苷胺类似物（一种强效且选择性的腺苷A1受体激动剂）对缺血性损伤的保护作用。
Eur J Pharmacol. 1999 Mar 26;369(3):313-7. doi: 10.1016/s0014-2999(99)00073-4.

本文引用的文献

1
Species Differences in Ligand Affinity at Central A-Adenosine Receptors.中枢A1-腺苷受体配体亲和力的种属差异。
Drug Dev Res. 1994 Sep;33(1):51-59. doi: 10.1002/ddr.430330109.
2
N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.
J Med Chem. 1999 Sep 9;42(18):3463-77. doi: 10.1021/jm960682u.
3
Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils.腺苷胺类似物（ADAC）缺血后给药：沙土鼠恢复情况分析
Eur J Pharmacol. 1996 Dec 5;316(2-3):171-9. doi: 10.1016/s0014-2999(96)00667-x.
4
Adenosine receptor ligands: differences with acute versus chronic treatment.腺苷受体配体：急性治疗与慢性治疗的差异
Trends Pharmacol Sci. 1996 Mar;17(3):108-13. doi: 10.1016/0165-6147(96)10002-x.
5
Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist.使用选择性腺苷A1受体激动剂治疗后，缺血性脑损伤和记忆缺陷减轻。
Eur J Pharmacol. 1996 Apr 29;302(1-3):43-8. doi: 10.1016/0014-2999(96)00101-x.
6
The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells.A3 腺苷受体是唯一能促进肥大细胞释放过敏介质的腺苷受体。
J Biol Chem. 1993 Aug 15;268(23):16887-90.
7
Chronic administration of selective adenosine A1 receptor agonist or antagonist in cerebral ischemia.在脑缺血中选择性腺苷A1受体激动剂或拮抗剂的长期给药。
Eur J Pharmacol. 1994 Apr 21;256(2):161-7. doi: 10.1016/0014-2999(94)90241-0.
8
Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and N-methyl-D-aspartate induced seizures in mice.慢性腺苷A1受体激动剂和拮抗剂：对小鼠受体密度及N-甲基-D-天冬氨酸诱导癫痫发作的影响
Eur J Pharmacol. 1994 Feb 21;253(1-2):95-9. doi: 10.1016/0014-2999(94)90762-5.
9
Adenosine: a prototherapeutic concept in neurodegeneration.腺苷：神经退行性变中的一种原治疗概念。
Ann N Y Acad Sci. 1995 Sep 15;765:163-78; discussion 196-7. doi: 10.1111/j.1749-6632.1995.tb16573.x.
10
Endogenously released adenosine regulates excitability in the in vitro hippocampus.内源性释放的腺苷调节体外培养海马体的兴奋性。
Epilepsia. 1980 Oct;21(5):541-8. doi: 10.1111/j.1528-1157.1980.tb04305.x.

Adenosine A1 receptor agonists as clinically viable agents for treatment of ischemic brain disorders.

作者信息

Bischofberger N, Jacobson K A, von Lubitz D K

机构信息

Gilead Sciences, Inc., Foster City, California 94404, USA.

出版信息

Ann N Y Acad Sci. 1997 Oct 15;825:23-9. doi: 10.1111/j.1749-6632.1997.tb48411.x.

DOI:10.1111/j.1749-6632.1997.tb48411.x
PMID:9369972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3445622/
Abstract
摘要