Narchi H, Kulaylat N
Al-Hasa Specialty Services Division, Saudi Aramco-Al-Hasa Health Center, Saudi Aramco Medical Services Organization, Mubarraz, Kingdom of Saudi Arabia.
Arch Dis Child. 1997 Sep;77(3):242-4. doi: 10.1136/adc.77.3.242.
The incidence of Down's syndrome was studied in 1870 infants of diabetic mothers out of 22,300 neonates born between January 1987 and April 1994 in our institution. All pregnancies were screened for diabetes and all cases of Down's syndrome were confirmed by chromosome analysis. Down's syndrome (all trisomy 21) was diagnosed in 35 infants: seven were born to mothers with gestational diabetes and 28 to non-diabetic mothers. The incidence of Down's syndrome was higher in infants of diabetic mothers (3.75 per 1000 v 1.36 per 1000) (p = 0.02) with a relative risk of 2.75. No significant difference was found in maternal age between both groups (p = 0.67) and the rate of Down's syndrome was higher in infants of diabetic mothers when compared with infants of non-diabetic mothers of similar age. Down's syndrome should be added to the congenital malformations already known to occur more frequently in infants of diabetic mothers.
在1987年1月至1994年4月期间，我们机构出生的22300例新生儿中，对1870例糖尿病母亲的婴儿进行了唐氏综合征发病率的研究。所有妊娠均进行了糖尿病筛查，所有唐氏综合征病例均经染色体分析确诊。35例婴儿被诊断为唐氏综合征（均为21 - 三体）：7例母亲患有妊娠期糖尿病，28例母亲无糖尿病。糖尿病母亲的婴儿中唐氏综合征的发病率较高（每1000例中3.75例对每1000例中1.36例）（p = 0.02），相对风险为2.75。两组母亲年龄无显著差异（p = 0.67），与年龄相似的非糖尿病母亲的婴儿相比，糖尿病母亲的婴儿中唐氏综合征的发生率更高。唐氏综合征应被添加到已知在糖尿病母亲的婴儿中更频繁发生的先天性畸形中。
