通过荧光原位杂交评估人类精子中YY非整倍体的父系年龄效应。
Paternal age effect of YY aneuploidy in human sperm, as assessed by fluorescence in situ hybridization.
作者信息
Kinakin B, Rademaker A, Martin R
机构信息
Department of Medical Genetics, University of Calgary, Alberta, Canada.
出版信息
Cytogenet Cell Genet. 1997;78(2):116-9. doi: 10.1159/000134641.
PMID:9371402
Abstract
Sperm samples were collected from 18 healthy men of various ages. Multicolor FISH was performed on each sample, using probes for the sex chromosomes and chromosome 1. A minimum of 10,000 sperm per donor was analyzed. The Pearson correlation coefficient was used to determine if there was an association between donor age and disomy frequency for the sex chromosomes.
摘要
从18名不同年龄段的健康男性中采集了精子样本。对每个样本进行了多色荧光原位杂交（Multicolor FISH），使用了性染色体和1号染色体的探针。每个供体至少分析了10000个精子。使用皮尔逊相关系数来确定供体年龄与性染色体二体频率之间是否存在关联。
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