Retrograde transport of horseradish peroxidase in sciatic nerve of rats and dystrophy mice.

The relationship between nerve or muscle activity and retrograde HRP transport was studied in rat Sciatic nerve and in dystrophy mice. sciatic nerve stimulation facilitated transport to 250% of control level, while colchicine decrease transport depending on dosage. Tendonectomy as well as colchicine treatment ultimately decreased HRP transport, but before the decrease, there was a transient facilitatory phase in both colchicine treated and tendonectomized rats. In dystrophy mice, almost twice as much nerve trunk injected HRP was transported as in control mice. This suggests that retrograde transport level increases in some stage of dystrophy.