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短期突触可塑性中离子电流的调制与递质释放的调节：动作电位的起伏

Modulation of ion currents and regulation of transmitter release in short-term synaptic plasticity: the rise and fall of the action potential.

作者信息

Klein M

机构信息

Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada.

出版信息

Invert Neurosci. 1995;1(1):15-24. doi: 10.1007/BF02331828.

DOI:10.1007/BF02331828
PMID:9372129
Abstract

Up and down-regulation of calcium and potassium conductances are associated with several forms of short-term synaptic modulation. Detailed investigation of synaptic plasticity in the marine gastropod Aplysia, and in other mollusks, indicates that synaptic transmission can be influenced in a number of ways by modulatory neurotransmitters acting through several second-messenger cascades. Modulation at the synapse itself occurs by means of the regulation of calcium current as well as through effects on processes directly involved in transmitter mobilization and exocytosis. Modulation of potassium current plays a major role in controlling neuronal excitability and may contribute to a lesser extent to the regulation of transmitter release through actions on the resting potential and on action potential configuration.

摘要

钙电导和钾电导的上调与下调与多种形式的短期突触调制相关。对海生腹足动物海兔及其他软体动物突触可塑性的详细研究表明，通过几种第二信使级联起作用的调制性神经递质能以多种方式影响突触传递。突触自身的调制是通过对钙电流的调节以及对直接参与递质动员和胞吐作用的过程的影响来实现的。钾电流的调制在控制神经元兴奋性方面起主要作用，并且可能在较小程度上通过对静息电位和动作电位形态的作用来对递质释放的调节有所贡献。

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Modulation of ion currents and regulation of transmitter release in short-term synaptic plasticity: the rise and fall of the action potential.短期突触可塑性中离子电流的调制与递质释放的调节：动作电位的起伏
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2
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5
Calcium levels measured in a presynaptic neurone of Aplysia under conditions that modulate transmitter release.在调节递质释放的条件下，对海兔的突触前神经元中的钙水平进行测量。
J Physiol. 1986 Jun;375:625-42. doi: 10.1113/jphysiol.1986.sp016137.
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引用本文的文献

1
Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.释放单个突触前末梢的特性，这些末梢在海兔感觉运动突触的同源抑制和异源易化期间被表达。
Front Cell Neurosci. 2013 Sep 24;7:165. doi: 10.3389/fncel.2013.00165. eCollection 2013.
2
Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.钙激活蛋白酶对于补充海兔培养的感觉运动突触中耗尽的囊泡储备至关重要。
Learn Mem. 2005 Jul-Aug;12(4):414-22. doi: 10.1101/lm.92105.
3
Regulation of spike initiation and propagation in an Aplysia sensory neuron: gating-in via central depolarization.

本文引用的文献

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Action-potential duration and the modulation of transmitter release from the sensory neurons of Aplysia in presynaptic facilitation and behavioral sensitization.动作电位持续时间以及感觉神经元中递质释放的调制在突触前易化和行为敏感化中的作用。
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Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture.在培养的海兔感觉运动突触处，活动和5-羟色胺对递质的易释放池以及兴奋-分泌偶联的调节作用。
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Ca2+-independent protein kinase C Apl II mediates the serotonin-induced facilitation at depressed aplysia sensorimotor synapses.不依赖钙离子的蛋白激酶C Apl II介导5-羟色胺诱导的海兔感觉运动突触抑制时的易化作用。
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Tachykinin-related peptide and GABA-mediated presynaptic inhibition of crayfish photoreceptors.速激肽相关肽与γ-氨基丁酸介导的小龙虾光感受器的突触前抑制
J Neurosci. 2000 Mar 1;20(5):1780-90. doi: 10.1523/JNEUROSCI.20-05-01780.2000.
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Activity and calcium-dependent mechanisms maintain reliable interneuron synaptic transmission in a rhythmic neural network.活性和钙依赖机制维持节律性神经网络中可靠的中间神经元突触传递。
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Sites of plasticity in the neural circuit mediating tentacle withdrawal in the snail Helix aspersa: implications for behavioral change and learning kinetics.在蜗牛（褐云玛瑙螺）介导触手缩回的神经回路中的可塑性位点：对行为变化和学习动力学的影响
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Interactions between depression and facilitation within neural networks: updating the dual-process theory of plasticity.神经网络中抑郁与易化之间的相互作用：更新可塑性的双过程理论
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Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila.果蝇逃逸回路习惯化过程中特定钾通道亚基功能贡献的遗传剖析。
J Neurosci. 1998 Mar 15;18(6):2254-67. doi: 10.1523/JNEUROSCI.18-06-02254.1998.
Roles of second messenger pathways in neuronal plasticity and in learning and memory. Insights gained from Aplysia.
第二信使通路在神经元可塑性以及学习和记忆中的作用。来自海兔的见解。
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Long-term changes in synthesis of intermediate filament protein, actin and other proteins in pleural sensory neurons of Aplysia produced by an in vitro analogue of sensitization training.通过致敏训练的体外类似物在海兔胸膜感觉神经元中产生的中间丝蛋白、肌动蛋白和其他蛋白质合成的长期变化。
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Differential cyclic AMP dependence of facilitation at Aplysia sensorimotor synapses as a function of prior stimulation: augmentation versus restoration of transmitter release.海兔感觉运动突触处易化作用的环磷酸腺苷差异性依赖性与先前刺激的关系：递质释放的增强与恢复
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Activation of cAMP-responsive genes by stimuli that produce long-term facilitation in Aplysia sensory neurons.通过在海兔感觉神经元中产生长期易化的刺激来激活环磷酸腺苷反应基因。
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Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation.海兔感觉神经元的成像终端证明了增强的钙离子内流在突触前易化中的作用。
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Long-term potentiation of Aplysia sensorimotor synapses in cell culture: regulation by postsynaptic voltage.细胞培养中海兔感觉运动突触的长期增强：由突触后电压调节
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C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia.C/EBP是海兔中长期易化巩固所必需的即早基因。
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10
Synaptic augmentation by 5-HT at rested Aplysia sensorimotor synapses: independence of action potential prolongation.5-羟色胺对静息状态下的海兔感觉运动突触的突触增强作用：动作电位延长的独立性。
Neuron. 1994 Jul;13(1):159-66. doi: 10.1016/0896-6273(94)90466-9.