Dawood M Y
Am J Obstet Gynecol. 1976 Jul 15;125(6):832-40. doi: 10.1016/0002-9378(76)90859-0.
Serum progesterone was measured by competitive protein-binding assay in 331 cases of normal pregnancy ranging from 6 to 42 weeks. Serial estimations of serum progesterone were performed in nine cases of severe hypertensive disorder of pregnancy, eight cases of twin pregnancy, three cases of twin pregnancy complicated by severe hypertensive disorder of pregnancy, three cases of triplet pregnancy, three cases of previous bad obstetric history, one case of anencephaly, and seven cases of intrauterine fetal death. Serum progesterone remained within normal range in severe hypertensive disorder of pregnancy and the levels were indistinguishable in cases of fetal growth retardation from those without growth retardation. In twin and triplet pregnancies, serum progesterone was within normal range or elevated and was usually higher than normal in twin pregnancies after weeks 33 to 34. Serum progesterone levels were normal in anencephalic pregnancy and in most cases of intrauterine fetal death. The findings are discussed with reference to placental hormonal activity. It is concluded that serum progesterone is a poor index of placental function.
采用竞争性蛋白结合分析法测定了331例妊娠6至42周的正常孕妇血清孕酮水平。对9例重度妊娠高血压疾病、8例双胎妊娠、3例合并重度妊娠高血压疾病的双胎妊娠、3例三胎妊娠、3例既往有不良产科史、1例无脑儿和7例胎儿宫内死亡病例进行了血清孕酮的系列测定。重度妊娠高血压疾病患者血清孕酮水平仍在正常范围内，胎儿生长受限患者与无生长受限患者的血清孕酮水平无差异。双胎和三胎妊娠时，血清孕酮水平在正常范围内或升高，33至34周后的双胎妊娠血清孕酮水平通常高于正常。无脑儿妊娠和大多数胎儿宫内死亡病例的血清孕酮水平正常。结合胎盘激素活性对这些结果进行了讨论。得出的结论是，血清孕酮不是胎盘功能的良好指标。
