Borna S, Bandarian M, Abdollahi A, Bandarian F, Malek M
Associate Professor, Department of Perinatology, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Radiol. 2011 Mar;8(1):33-7. Epub 2011 Mar 30.
BACKGROUND/OBJECTIVE: To verify whether progesterone concentration is changed in the maternal serum of intra-uterine growth retardation (IUGR) pregnancies and to assess if there is a relationship between maternal progesterone and fetal Doppler velocimetry.
Thirty-five patients with intrauterine growth retardation infants and thirty-seven pregnant women with appropriate for gestational age (AGA) fetuses were enrolled in the study. Maternal progesterone serum was determined. Doppler velocimetry of umbilical and middle cerebral arteries (MCA) were obtained in all fetuses.
Maternal progesterone level in IUGR infants (58.49±7.06 ng/ml) had no significant difference with AGA fetuses (58.13±7.87 ng/ml) (p=0.96). In the IUGR group, umbilical artery resistive index (RI), pulsatility index (PI) and systolic/diastolic (S/D) ratio were higher than the normal group (p<0.001), and MCA RI (p value=0.014) and PI (p=0.012) were significantly less than the IUGR group. Besides, RI C/U in the IUGR group was significantly less than the normal group (p<0.001). A negative significant correlation was detected between maternal progesterone level and MCA PI (r=-0.38) and RI (r=-0.38) in the AGA group.
It seems that progesterone has no effect on fetal placental circulation and serum progesterone can not discriminate IUGR infants from AGA infants. Progesterone is a poor marker for placental dysfunction.
背景/目的：验证宫内生长受限（IUGR）妊娠孕妇血清中孕酮浓度是否发生变化，并评估母体孕酮与胎儿多普勒血流速度测定之间是否存在关联。
本研究纳入了35例宫内生长受限婴儿的孕妇和37例孕龄适配（AGA）胎儿的孕妇。测定母体血清孕酮水平。对所有胎儿进行脐动脉和大脑中动脉（MCA）的多普勒血流速度测定。
IUGR婴儿的母体孕酮水平（58.49±7.06 ng/ml）与AGA胎儿（58.13±7.87 ng/ml）相比无显著差异（p = 0.96）。在IUGR组中，脐动脉阻力指数（RI）、搏动指数（PI）和收缩/舒张（S/D）比值高于正常组（p < 0.001），而MCA的RI（p值 = 0.014）和PI（p = 0.012）显著低于IUGR组。此外，IUGR组的RI C/U显著低于正常组（p < 0.001）。在AGA组中，母体孕酮水平与MCA的PI（r = -0.38）和RI（r = -0.38）之间存在显著负相关。
孕酮似乎对胎儿胎盘循环无影响，血清孕酮无法区分IUGR婴儿和AGA婴儿。孕酮不是胎盘功能障碍的良好标志物。
