Stern Y, Lisnyansky I, Shpitzer T, Nativ O, Medalia O, Feinmesser R, Aronson M
Department of Otolaryngology-Head and Neck Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
Otolaryngol Head Neck Surg. 1997 Nov;117(5):501-3. doi: 10.1016/s0194-5998(97)70021-4.
Extrathyroidal invasion of papillary carcinoma of the thyroid gland has a very bad prognosis. A retrospective study was performed on 40 specimens from patients with papillary carcinoma of the thyroid gland to find out whether DNA ploidy correlated with aggressive tumor behavior. The nuclear DNA content of 20 locally aggressive papillary thyroid carcinomas was studied by flow cytometry. The results were compared with those of a matched control group of 20 patients with noninvasive papillary tumors. Forty percent of the tumors with spread to extrathyroid tissue were aneuploid, whereas all the tumors without such extension were diploid. This difference was statistically significant (p < 0.003). The data suggest that the differentiation of locally noninvasive and invasive papillary thyroid carcinomas may be potentially possible by nuclear DNA determination.
甲状腺乳头状癌的甲状腺外侵犯预后很差。对40例甲状腺乳头状癌患者的标本进行了一项回顾性研究，以确定DNA倍性是否与侵袭性肿瘤行为相关。通过流式细胞术研究了20例局部侵袭性甲状腺乳头状癌的核DNA含量。将结果与20例非侵袭性乳头状肿瘤患者的配对对照组进行比较。扩散至甲状腺外组织的肿瘤中有40%为非整倍体，而所有无此类扩展的肿瘤均为二倍体。这种差异具有统计学意义（p < 0.003）。数据表明，通过核DNA测定可能潜在地区分局部非侵袭性和侵袭性甲状腺乳头状癌。
