Laurell C G, Wickström K, Zetterström C, Lundgren B
St. Erik's Eye Hospital, Stockholm, Sweden.
Acta Ophthalmol Scand. 1997 Aug;75(4):401-4. doi: 10.1111/j.1600-0420.1997.tb00398.x.
We compared the inflammatory response after phacoemulsification and conventional extracapsular lens extraction in New Zealand albino rabbits.
One eye was selected at random and phacoemulsification was performed. Extracapsular lens extraction was done in the fellow eye. In both eyes a polymethylmetacrylate intraocular lens was implanted into the capsular bag and the wound was sutured with a 9-0 polypropylene continuous suture. The levels of prostaglandin E2 in aqueous humour and wet mass of the iris-ciliary bodies were measured at day 1. The number of white blood cells and protein levels in the aqueous humour were measured at day 1, 3, 7, 14 and 30. Corneal thickness was estimated with pachymetry.
Prostaglandin E2 levels and wet masses of iris-ciliary bodies were significantly higher after extracapsular lens extraction, which also induced significantly higher white blood cells counts at day 1 and 3 and higher protein levels at day 7. Extracapsular lens extraction caused more corneal edema at day 3, 7 and 14.
The results suggest that phacoemulsification induced less surgical trauma with less breakdown of the blood-aqueous barrier.
我们比较了新西兰白兔白内障超声乳化吸除术与传统囊外白内障摘除术后的炎症反应。
随机选择一只眼进行超声乳化吸除术，另一只眼行囊外白内障摘除术。两只眼均在囊袋内植入聚甲基丙烯酸甲酯人工晶状体，伤口用9-0聚丙烯连续缝线缝合。在第1天测量房水中前列腺素E2水平和虹膜睫状体湿重。在第1、3、7、14和30天测量房水中白细胞数量和蛋白质水平。用测厚仪估计角膜厚度。
囊外白内障摘除术后前列腺素E2水平和虹膜睫状体湿重显著更高，在第1天和第3天白细胞计数也显著更高，在第7天蛋白质水平更高。囊外白内障摘除术在第3、7和14天引起更多角膜水肿。
结果表明，超声乳化吸除术引起的手术创伤较小，血-房水屏障破坏较少。
