经免疫组织化学和电子显微镜证实的虹膜平滑肌瘤。
A leiomyoma of the iris documented by immunohistochemistry and electron microscopy.
作者信息
Eide N, Farstad I N, Røger M
机构信息
University Eye Department, The National Hospital, Rikshospitalet, University of Oslo, Norway.
出版信息
Acta Ophthalmol Scand. 1997 Aug;75(4):470-3. doi: 10.1111/j.1600-0420.1997.tb00417.x.
PURPOSE
To report an iris leiomyoma documented in accordance with today's stricter diagnostic criteria.
METHODS
Light microscopy, immunohistochemistry and electron microscopy were performed on the 3 mm ball-like, greyish-white vascularized tumour of the iris, close to the sphincter pupillae.
RESULTS
Light microscopy of the extirpated neoplasm showed the characteristic appearance of a leiomyoma with densely packed spindle-shaped cells, with oval nuclei and granular cytoplasm. On electron microscopic examination the tumour exhibited the characteristic features of a smooth muscle neoplasm. The immunohistochemistry was consistent with a myogenic tumour because the tumour cells were positive for smooth muscle actin and desmin, but negative for S-100 and melanin.
CONCLUSION
The case illustrated the necessity of performing ancillary procedures such as electron microscopy and immunohistochemistry to substantiate a correct, although rare diagnosis.
目的
报告一例依据当今更严格诊断标准确诊的虹膜平滑肌瘤。
方法
对靠近瞳孔括约肌的虹膜处一个3毫米球状、灰白色、有血管的肿瘤进行了光镜检查、免疫组化和电镜检查。
结果
切除肿瘤的光镜检查显示平滑肌瘤的典型外观，有密集排列的梭形细胞，核呈椭圆形，细胞质呈颗粒状。电镜检查显示该肿瘤具有平滑肌肿瘤的特征性表现。免疫组化结果与肌源性肿瘤相符，因为肿瘤细胞平滑肌肌动蛋白和结蛋白呈阳性，但S - 100和黑色素呈阴性。
结论
该病例说明了进行电子显微镜检查和免疫组化等辅助检查对于证实一个正确的（尽管罕见）诊断的必要性。
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