Rengstorff R, Petrali J, Sim V
Am J Optom Physiol Opt. 1976 Jan;53(1):41-2. doi: 10.1097/00006324-197601000-00007.
Acetone is used as a solvent for chemicals in skin sensitization studies. Its low cost, high solvent powers, and comparative lack of toxicity make it one of the most widely used industrial solvents. Absorption of acetone through the skin is not considered hazardous; however, in an earlier study we found that acetone caused cataracts in a large group of guinea pigs when small multiple doses were administered either topically or intracutaneously on the backs of these animals. No cataracts were found when two rabbits were tested. The purpose of the present study is to repeat the earlier study using more rabbits. Here, none of the 10 experimental rabbits or the 10 control rabbits developed any lens abnormalities. Those drugs and toxic substances that have produced cataracts in rabbits are described.
在皮肤致敏研究中，丙酮用作化学物质的溶剂。其成本低、溶解力强且相对无毒，使其成为应用最广泛的工业溶剂之一。经皮肤吸收丙酮不被视为有害；然而，在早期一项研究中，我们发现，当在一大群豚鼠背部局部或皮内多次给予小剂量丙酮时，丙酮会导致这些动物出现白内障。对两只兔子进行测试时未发现白内障。本研究的目的是使用更多兔子重复早期研究。在此，10只实验兔和10只对照兔均未出现任何晶状体异常。文中还描述了那些在兔子身上引发白内障的药物和有毒物质。
