Rengstorff R H, Khafagy H I
Arch Toxicol. 1985 Oct;58(1):64-6. doi: 10.1007/BF00292620.
The purpose of the present investigation was to determine the concentration of ascorbate in the aqueous humor of guinea pigs over a 1-year period following the cutaneous application of a potential cataractogenic agent, acetone. Forty young guinea pigs received 15 ml acetone in small doses on their backs over a 6-week period; the ascorbate in their aqueous humor did not increase above 10 mg/100 ml during a 1-year test period. Ten control animals received only saline on their backs and the ascorbate concentrations steadily increased from 12 to over 18 mg/100 ml during the same time period. Three months after acetone treatment 12 animals (30%) developed cataracts and their ascorbate levels dropped to below 9 mg/100 ml after 1 year.
本研究的目的是确定在经皮应用潜在致白内障剂丙酮后1年期间豚鼠房水中抗坏血酸盐的浓度。40只幼年豚鼠在6周内背部接受小剂量的15毫升丙酮；在1年的测试期内，它们房水中的抗坏血酸盐含量未超过10毫克/100毫升。10只对照动物背部仅接受生理盐水，在同一时期内抗坏血酸盐浓度从12毫克/100毫升稳步增加到超过18毫克/100毫升。丙酮处理3个月后，12只动物（30%）出现白内障，1年后它们的抗坏血酸盐水平降至9毫克/100毫升以下。
