感染卡波西肉瘤相关疱疹病毒/人疱疹病毒8型的BCBL-1淋巴瘤细胞系可在严重联合免疫缺陷小鼠中引发肿瘤，但无法将病毒传播至人外周血单个核细胞移植体。
The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft.
作者信息
Picchio G R, Sabbe R E, Gulizia R J, McGrath M, Herndier B G, Mosier D E
机构信息
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
Virology. 1997 Nov 10;238(1):22-9. doi: 10.1006/viro.1997.8822.
The body-cavity-based lymphoma cell line BCBL-1, which is infected with Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8, was injected alone or with human peripheral blood mononuclear cells into SCID mice. Immunoblastic lymphomas developed at or near the site of injection. The lymphomas appeared to derive exclusively from the injected BCBL-1 cells and not from the injected human PBMC. The tumors elicited a marked murine angiogenic response, but known angiogenic cytokines were not detected in BCBL-1 cells. Transfer of BCBL-1 cells to SCID mice may represent an in vivo model for the study of KSHV/HHV8-stimulated angiogenesis.
将感染了卡波西肉瘤相关疱疹病毒/人类疱疹病毒8的基于体腔的淋巴瘤细胞系BCBL-1单独或与人外周血单个核细胞一起注射到SCID小鼠体内。在注射部位或其附近发生了免疫母细胞淋巴瘤。这些淋巴瘤似乎完全来源于注射的BCBL-1细胞，而非注射的人外周血单个核细胞。肿瘤引发了明显的小鼠血管生成反应，但在BCBL-1细胞中未检测到已知的血管生成细胞因子。将BCBL-1细胞转移至SCID小鼠体内可能代表一种用于研究卡波西肉瘤相关疱疹病毒/人类疱疹病毒8刺激的血管生成的体内模型。
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