Parker P M, Openshaw H, Forman S J
Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010-3000, USA.
Curr Opin Rheumatol. 1997 Nov;9(6):513-9. doi: 10.1097/00002281-199711000-00006.
A polymyositis syndrome has been described as a rare complication in patients who develop chronic graft-versus-host disease after allogeneic bone marrow transplantation. Chronic graft-versus-host disease is a cellular immune-mediated donor bone marrow versus patient rejection reaction, which may also lead to an autoimmune pathologic process. Chronic graft-versus-host disease-related polymyositis appears to be very similar to idiopathic myositis in its clinicopathologic presentation; chronic graft-versus-host disease-related myositis responds well to prednisone but cyclosporine may be an important component of second-line therapy due to its efficacy in controlling underlying chronic graft-versus-host disease.
多肌炎综合征已被描述为同种异体骨髓移植后发生慢性移植物抗宿主病患者的一种罕见并发症。慢性移植物抗宿主病是一种细胞免疫介导的供体骨髓对患者的排斥反应，这也可能导致自身免疫病理过程。慢性移植物抗宿主病相关的多肌炎在临床病理表现上似乎与特发性肌炎非常相似；慢性移植物抗宿主病相关的肌炎对泼尼松反应良好，但环孢素可能是二线治疗的重要组成部分，因为它在控制潜在的慢性移植物抗宿主病方面具有疗效。
