Sabbah A, Sainte-Laudy J, Drouet M, Lauret M G, Loiry M L, el Founini M, Oreac J, Guitton J, Doucet M
Laboratoire d'Immuno-Allergologie-CHRU, Angers.
Allerg Immunol (Paris). 1997 Jul;29 Spec No:6-10.
Food allergy is becoming more frequent, with 6% of asthmatics reporting an isolated food allergy, and 5 to 6% of atopic dermatitis patients also have either a single or multiple true food allergy. There is value in immuno-biological diagnosis by: Measurement of total serum IgE. Measurement of mono-allergen-specific IgE, following a measurement by a multi-allergen of the Trophatope type. A study of elimination of foods for 2 or 3 months followed by their re-introduction. Oral provocation tests in a hospital environment under clinical control and subsequent measurement of the mediators:-Plasma histamine, tryptase, and urinary methylhistamine to give proof of responsibility of the food allergen. Nowadays, it is perfectly possible to include in diagnosis the new technologies of the test of activation of basophils/or lymphocytes by means of flow cytometry.
食物过敏越来越常见，6%的哮喘患者报告有单纯食物过敏，5%至6%的特应性皮炎患者也有单一或多种真正的食物过敏。免疫生物学诊断具有重要价值，具体方法如下：检测血清总IgE；在使用Trophatope型多过敏原检测后，检测单一过敏原特异性IgE；进行为期2至3个月的食物排除研究，随后重新引入这些食物；在医院环境中，在临床控制下进行口服激发试验，并随后检测介质——血浆组胺、类胰蛋白酶和尿甲基组胺，以证明食物过敏原的责任。如今，通过流式细胞术检测嗜碱性粒细胞/淋巴细胞活化的新技术完全可以纳入诊断。
