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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Minami M, Kimura S, Endo T, Hamaue N, Hirafuji M, Monma Y, Togashi H, Yoshioka M, Saito H, Watanabe S, Kobayashi T, Okuyama H

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.

Gen Pharmacol. 1997 Sep;29(3):401-7. doi: 10.1016/s0306-3623(96)00487-9.

Dietary docosahexaenoic acid (DHA) suppressed the age-dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.

饮食中的二十二碳六烯酸（DHA）抑制了收缩压随年龄增长的升高，并延长了易中风自发性高血压大鼠（SHRSP）的平均存活时间。2. 饮食中的DHA（占饮食的1%和5%）改变了SHRSP的昼夜节律，导致其在黑暗期的活动显著增加。在中风发作时，所有对照SHRSP（DHA为0%）均出现与明暗周期不同步以及新的生物节律。经DHA处理的SHRSP未表现出此类行为变化。3. 这些效应伴随着血浆和大脑皮质中DHA水平的升高以及花生四烯酸（AA）水平的降低。4. 得出的结论是，饮食中的DHA可抑制高血压的发展以及与中风相关的行为变化，从而延长SHRSP的寿命。

Minami M, Kimura S, Endo T, Hamaue N, Hirafuji M, Monma Y, Togashi H, Yoshioka M, Saito H, Watanabe S, Kobayashi T, Okuyama H

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.

Gen Pharmacol. 1997 Sep;29(3):401-7. doi: 10.1016/s0306-3623(96)00487-9.

Dietary docosahexaenoic acid (DHA) suppressed the age-dependent increase in systolic blood pressure and prolonged the average survival time of stroke-prone spontaneously hypertensive rats (SHRSP). 2. Dietary DHA (1% and 5% in diets) altered the circadian rhythm of SHRSP, causing significant increases in ambulatory activity during the dark period. At the onset of stroke, desynchronization with light and dark phases and new biological rhythms were noted in all of the control SHRSP (DHA 0%). DHA treated SHRSP did not show such behavioral changes. 3. These effects were accompanied by the increase of DHA and the decrease of AA levels in plasma and brain cortex. 4. It was concluded that dietary DHA suppresses the development of hypertension and stroke-related behavioral changes, resulting in prolongation of the SHRSP's life span.

饮食中的二十二碳六烯酸（DHA）抑制了收缩压随年龄增长的升高，并延长了易中风自发性高血压大鼠（SHRSP）的平均存活时间。2. 饮食中的DHA（占饮食的1%和5%）改变了SHRSP的昼夜节律，导致其在黑暗期的活动显著增加。在中风发作时，所有对照SHRSP（DHA为0%）均出现与明暗周期不同步以及新的生物节律。经DHA处理的SHRSP未表现出此类行为变化。3. 这些效应伴随着血浆和大脑皮质中DHA水平的升高以及花生四烯酸（AA）水平的降低。4. 得出的结论是，饮食中的DHA可抑制高血压的发展以及与中风相关的行为变化，从而延长SHRSP的寿命。