Minami M, Togashi H, Koike Y, Saito H, Nakamura N, Yasuda H
Stroke. 1985 Jan-Feb;16(1):44-8. doi: 10.1161/01.str.16.1.44.
In order to elucidate the behavioral changes related to stroke, ambulatory activity and water drinking were observed in stroke-prone spontaneously hypertensive rats (SHRSP). Age matched male SHRSP and Wistar Kyoto rats (WKY) were subjected to a 12 hour light and dark alternation cycle. Ambulation and drinking activity counts were determined simultaneously with an Ambulo-Drinkometer. Before stroke, ambulation and drinking activity counts in the dark phase (82%) were higher than those in the light phase (18%). Both parameters were well synchronized with the light and dark alternation cycle. With aging, daily ambulation decreased while daily drinking activity increased in SHRSP and WKY. Daily ambulation and drinking activity in 15 and 30 week old SHRSP were greater than those of WKY. It was demonstrated with an Ambulo-Drinkometer that SHRSP undergo specific behavioral changes before the onset of stroke. For instance, the 40-60 week old SHRSP showed significant individual variation in both ambulation and drinking activity. This desynchronization with the light and dark alternation cycle was followed by stroke. Twenty seven autopsies showed 11 cerebral infarctions, 10 cerebral hemorrhage and 6 cerebral hemorrhage with infarctions to be the causes of death.
为了阐明与中风相关的行为变化，对易中风自发性高血压大鼠（SHRSP）的自主活动和饮水情况进行了观察。将年龄匹配的雄性SHRSP和Wistar Kyoto大鼠（WKY）置于12小时明暗交替循环中。使用活动-饮水监测仪同时测定活动和饮水活动次数。中风前，黑暗期（82%）的活动和饮水活动次数高于光明期（18%）。这两个参数都与明暗交替循环良好同步。随着年龄增长，SHRSP和WKY的每日活动量减少而每日饮水量增加。15周龄和30周龄SHRSP的每日活动和饮水活动量均大于WKY。活动-饮水监测仪显示，SHRSP在中风发作前会出现特定的行为变化。例如，40 - 60周龄的SHRSP在活动和饮水活动方面均表现出显著的个体差异。这种与明暗交替循环的不同步随后导致了中风。27例尸检显示，11例为脑梗死，10例为脑出血，6例为脑出血合并梗死，这些是死亡原因。
