Sovertkova L S
Gig Sanit. 1997 Sep-Oct(5):3-5.
The experiment was conducted on white noninbred rats receiving different concentrations of the nitrosamine (NA) precursors NO2 and amidopyrinum. Carcinogenic NAs were determined in the organs of the animals that had inhaled them at concentrations of 0.4, 0.8, and 4.0 mg/m3. There was an increase in tumors in chronic experiments on exposure to NA in the same doses as compared with the controls. It was found that the ambient air NO2 level of 0.4 mg/m3 (MAC 10 mg/m3) should be considered to be hazardous due to the fact that there might be exogenous and endogenous syntheses and that the NA might exert a carcinogenic effect.
该实验在接受不同浓度亚硝胺（NA）前体二氧化氮（NO₂）和氨基比林的非近亲繁殖白色大鼠身上进行。测定了吸入浓度为0.4、0.8和4.0毫克/立方米的动物器官中的致癌性亚硝胺。与对照组相比，在相同剂量的亚硝胺慢性暴露实验中，肿瘤数量有所增加。研究发现，环境空气中0.4毫克/立方米的二氧化氮水平（最高容许浓度为10毫克/立方米）应被视为有害，因为可能存在外源性和内源性合成，且亚硝胺可能会产生致癌作用。
