口腔底部基底样鳞状细胞癌：一种细胞系的特征

Basaloid-squamous cell carcinoma of the floor of the mouth: characterization of a cell line.

作者信息

Abiko Y, Okumura K, Ohuchi T, Konishi T, Kanazawa M, Kaku T

机构信息

Department of Oral Pathology, School of Dentistry, Health Sciences University of Hokkaido, Japan.

出版信息

J Oral Pathol Med. 1997 Sep;26(8):367-70. doi: 10.1111/j.1600-0714.1997.tb00232.x.

DOI:10.1111/j.1600-0714.1997.tb00232.x

PMID:9379426

Abstract

Since it was first described in 1986, basaloid-squamous cell carcinoma (BSC) has been considered a distinct variant of squamous cell carcinoma that occurs in a variety of anatomic sites, including the head and neck region. We report the characterization of the first cell line established from a basaloid-squamous cell carcinoma of the floor of the mouth. The cell line exhibited a highly invasive capacity, indicating that BSC has very aggressive behavior. This cell line may be a useful model for elucidation of the biological characteristics of BSC.

摘要

自1986年首次被描述以来，基底样鳞状细胞癌（BSC）一直被认为是鳞状细胞癌的一种独特变体，可发生于包括头颈部区域在内的多种解剖部位。我们报告了从一例口底基底样鳞状细胞癌建立的首个细胞系的特征。该细胞系表现出高度侵袭能力，表明BSC具有非常侵袭性的行为。该细胞系可能是阐明BSC生物学特性的有用模型。