交沙霉素和蔷薇霉素：与红霉素和克林霉素的体外比较
Josamycin and rosamicin: in vitro comparisons with erythromycin and clindamycin.
作者信息
Shadomy S, Tipple M, Paxton L
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):773-5. doi: 10.1128/AAC.10.4.773.
Abstract
The macrolide antibiotics josamycin and rosamicin were compared in vitro with erythromycin for activity against Staphylococcus aureus, S. epidermidis, and enterococci and with clindamycin for activity against a variety of anaerobic organisms. Rosamicin and erythromycin were similar in activity and superior to josamycin against aerobic cocci. Most isolates of S. aureus (96%), S. epidermidis (79%), and the enterococci (87%) were inhibited by 1.56 mug of either of the new macrolide compounds per ml. Clindamycin was the most active compound against the anaerobic organisms.
摘要
将大环内酯类抗生素交沙霉素和蔷薇霉素在体外与红霉素进行比较，以观察其对金黄色葡萄球菌、表皮葡萄球菌和肠球菌的活性，并与克林霉素比较其对多种厌氧菌的活性。蔷薇霉素和红霉素活性相似，且在抗需氧球菌方面优于交沙霉素。每毫升含1.56微克这两种新大环内酯类化合物中的任何一种，就能抑制大多数金黄色葡萄球菌（96%）、表皮葡萄球菌（79%）和肠球菌（87%）分离株。克林霉素是对厌氧菌活性最强的化合物。
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