多胎妊娠中的血清免疫球蛋白
Serum immunoglobulins in multiple pregnancy.
作者信息
Bryan E M, Slavin B, Nicholson E
出版信息
Arch Dis Child. 1976 May;51(5):354-9. doi: 10.1136/adc.51.5.354.
The concentrations of immunoglobulins (Ig) G.A.M. and E were determined in paired umbilical cord and maternal sera in 50 twin pregnancies. Mean IgG levels were higher in cord than maternal sera and in most cases the cord IgG level related more closely to that of the other twin than to either maternal level or birthweight, and was in the range for singletons of the same gestational age. The three cases of fetofetal transfusion syndrome were exceptional in the large difference between IgG concentrations in recipient and donor twins. The discrepancy was much greater than that found between the levels of proteins produced by the fetus, suggesting a disturbance in maternofetal placental transfer. IgM was detected in all cord sera, with one exception, and the level was not related to order of birth. IgA was detected in 16% of cord sera, 13% in sera from first borns. IgE was detected in only 8% of cord sera and there was no evidence of placental transfer.
对50例双胎妊娠的脐带血和母血配对样本测定了免疫球蛋白（Ig）G、A、M和E的浓度。脐带血中IgG的平均水平高于母血，在大多数情况下，脐带血IgG水平与另一胎儿的IgG水平关系更为密切，而与母血水平或出生体重的关系则较弱，且处于相同孕周单胎的范围内。3例胎儿-胎儿输血综合征的病例表现特殊，受血儿和供血儿双胞胎的IgG浓度差异很大。这种差异远大于胎儿产生的蛋白质水平之间的差异，提示母胎胎盘转运存在障碍。除1例例外，所有脐带血中均检测到IgM，其水平与出生顺序无关。16%的脐带血中检测到IgA，头胎婴儿血清中IgA的检出率为13%。仅8%的脐带血中检测到IgE，且无胎盘转运的证据。
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