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小胶质细胞中葡萄糖转运蛋白Glut 5的表达

Glucose transporter Glut 5 expression in microglial cells.

作者信息

Payne J, Maher F, Simpson I, Mattice L, Davies P

机构信息

Pathology Department, Albert Einstein College of Medicine, Bronx, New York 1046, USA.

出版信息

Glia. 1997 Nov;21(3):327-31. doi: 10.1002/(sici)1098-1136(199711)21:3<327::aid-glia7>3.0.co;2-1.

DOI:10.1002/(sici)1098-1136(199711)21:3<327::aid-glia7>3.0.co;2-1
PMID:9383041
Abstract

Glut 5 is a member of a family of facilitative glucose transporter proteins that are involved in the transportation of glucose and/or fructose across plasma membranes. Glut 5 is one of three isoforms expressed in brain. Using immunocytochemical and immunoblotting techniques in formalin fixed tissue, we have shown that Glut 5 is exclusively expressed in microglial cells of the human and rat brain. Our data demonstrate that unlike other microglial markers, Glut 5 can be used as a microglial marker in formalin fixed tissue.

摘要

葡萄糖转运蛋白5(Glut 5)是易化性葡萄糖转运蛋白家族的成员之一,该家族参与葡萄糖和/或果糖跨质膜的转运。Glut 5是在大脑中表达的三种亚型之一。我们运用免疫细胞化学和免疫印迹技术对福尔马林固定组织进行研究,结果表明Glut 5仅在人和大鼠大脑的小胶质细胞中表达。我们的数据表明,与其他小胶质细胞标志物不同,Glut 5可作为福尔马林固定组织中的小胶质细胞标志物。

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