Ward N M, Sharkey J, Brown V J
School of Psychology, University of St. Andrews, Scotland.
Behav Neurosci. 1997 Oct;111(5):1133-45. doi: 10.1037//0735-7044.111.5.1133.
Evaluating the efficacy of neuroprotective drugs in rat models of focal cerebral ischemia has involved histological and behavioral batteries to examine treatment outcome. However, the behavioral tests used to date provide little insight into the nature of the neurological impairments. To provide an analysis of a possible "neglect" syndrome after occlusion of the middle cerebral artery, M. I. Posner's (1980) visual attentional paradigm was adapted for use in the rat. A paw-reaching task and a test of somatosensory "neglect" also were used to assess forelimb sensorimotor function. The lesion group displayed unilateral deficits; however, there was no evidence of attentional dysfunction. Results are consistent with the conclusion that the behavioral deficits identified arise from a somatosensory deficit rather than hemineglect due to dysfunctional spatial attention.
评估神经保护药物在局灶性脑缺血大鼠模型中的疗效涉及组织学和行为学检测以检查治疗结果。然而，迄今为止所使用的行为测试对神经损伤的本质了解甚少。为了分析大脑中动脉闭塞后可能出现的“忽视”综合征，对M. I. 波斯纳（1980年）的视觉注意力范式进行了调整以用于大鼠。还使用了前爪够物任务和躯体感觉“忽视”测试来评估前肢感觉运动功能。损伤组表现出单侧缺陷；然而，没有注意力功能障碍的证据。结果与以下结论一致，即所确定的行为缺陷源于躯体感觉缺陷而非由于空间注意力功能障碍导致的半侧忽视。
