Misra V K, Agirbasli M, Fischell T A
Division of Cardiology/Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Clin Cardiol. 1997 Nov;20(11):915-22. doi: 10.1002/clc.4960201104.
Substantial evidence of postangioplasty vasoconstriction is available, both at the dilated site and distal to balloon injury, demonstrating its frequent occurrence. It is likely that even mild or moderate vasoconstriction at the site of balloon injury may create flow turbulence, promoting platelet aggregation and contributing to thrombotic vessel closure. The regulation of arterial smooth muscle tone is a complex process and should be distinguished from elastic recoil, which occurs at the site of balloon injury due to passive elastic properties of the artery, generally immediately after balloon deflation. The contribution of a variety of messengers generated by humoral, neurogenic, myogenic, and endothelium-derived factors in this regulatory process has been implicated. The possible mechanisms of post-percutaneous transluminal coronary angioplasty vasoconstriction at the dilated site (local) and in segments of coronary artery beyond the dilated site (distal) are reviewed in this article.
血管成形术后血管收缩的大量证据是存在的，在扩张部位及球囊损伤部位的远端均有，表明其经常发生。很可能即使球囊损伤部位的血管收缩为轻度或中度，也可能产生血流紊乱，促进血小板聚集并导致血管血栓性闭塞。动脉平滑肌张力的调节是一个复杂的过程，应与弹性回缩区分开来，弹性回缩是由于动脉的被动弹性特性在球囊损伤部位发生的，通常在球囊放气后立即出现。体液、神经源性、肌源性和内皮衍生因子产生的多种信使在这一调节过程中的作用已被提及。本文综述了经皮腔内冠状动脉成形术后扩张部位（局部）及扩张部位以外的冠状动脉节段（远端）血管收缩的可能机制。
