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1
The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.某些双硫仑类似物对绵羊肝脏醛脱氢酶的影响。
Biochem J. 1976 May 1;155(2):445-8. doi: 10.1042/bj1550445.
2
The separation of sheep liver cytoplasmic and mitochondrial aldehyde dehydrogenases by isoelectric focusing, and observations on the purity of preparations of the cytoplasmic enzyme, and their sensitivity towards inhibition by disulfiram.通过等电聚焦法分离绵羊肝脏细胞质和线粒体醛脱氢酶，以及对细胞质酶制剂纯度及其对双硫仑抑制敏感性的观察。
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3
The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.双硫仑对绵羊肝脏醛脱氢酶的影响。
Biochem J. 1975 Nov;151(2):407-12. doi: 10.1042/bj1510407.
4
Studies on the interaction between disulfiram and sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑与羊肝胞质醛脱氢酶相互作用的研究
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The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram.利用pH梯度离子交换色谱法从线粒体酶污染中分离绵羊肝脏细胞质醛脱氢酶，并对纯细胞质酶与双硫仑之间的相互作用进行观察。
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6
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Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑和2,2'-二硫代二吡啶对绵羊肝脏细胞质醛脱氢酶的脱氢酶和酯酶活性作用的进一步研究
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Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram.人类乙醛脱氢酶：双硫仑的抑制机制
Science. 1982 May 7;216(4546):637-9. doi: 10.1126/science.7071604.

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Exploring the structural requirements for inhibition of the ubiquitin E3 ligase breast cancer associated protein 2 (BCA2) as a treatment for breast cancer.探讨抑制泛素 E3 连接酶乳腺癌相关蛋白 2（BCA2）的结构要求，作为治疗乳腺癌的一种方法。
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Further studies of the action of disulfiram and 2,2'-dithiodipyridine on the dehydrogenase and esterase activities of sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑和2,2'-二硫代二吡啶对绵羊肝脏细胞质醛脱氢酶的脱氢酶和酯酶活性作用的进一步研究
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7
Effect of some thiocarbamate compounds on aldehyde dehydrogenase and implications for the disulfiram ethanol reaction.某些硫代氨基甲酸盐化合物对乙醛脱氢酶的影响及其与双硫仑-乙醇反应的关系
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8
Studies on the interaction between disulfiram and sheep liver cytoplasmic aldehyde dehydrogenase.双硫仑与羊肝胞质醛脱氢酶相互作用的研究
Biochem J. 1978 Oct 1;175(1):83-90. doi: 10.1042/bj1750083.
9
2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.2,2'-二硫代二吡啶激活醛脱氢酶，并保护该酶免受双硫仑的失活作用。
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本文引用的文献

1
INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM.双硫仑对多巴胺-β-羟化酶的抑制作用
Life Sci (1962). 1964 Jul;3:763-7. doi: 10.1016/0024-3205(64)90031-1.
2
The antabuse effect of some compounds related to antabuse and cyanamide.一些与戒酒硫和氰胺相关的化合物的戒酒硫样作用。
Acta Pharmacol Toxicol (Copenh). 1952;8(4):329-37. doi: 10.1111/j.1600-0773.1952.tb02910.x.
3
Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiram.二乙基二硫代氨基甲酸甲酯。双硫仑的一种代谢产物。
Biochem Pharmacol. 1972 Jan 15;21(2):219-30. doi: 10.1016/0006-2952(72)90272-9.
4
Interaction between tetraethylthiuram disulfide and the sulfhydryl groups of D-amino acid oxidase and of hemoglobin.二硫化四乙秋兰姆与D-氨基酸氧化酶及血红蛋白的巯基之间的相互作用。
J Biol Chem. 1966 Dec 25;241(24):5941-8.
5
A sensitive radioassay for sulfhydryl groups with tetraethylthiuram disulfide.一种用二硫化四乙基秋兰姆进行巯基检测的灵敏放射分析方法。
J Biol Chem. 1966 Jul 10;241(13):3036-40.
6
Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver.绵羊肝脏中醛脱氢酶的细胞内定位及特性
Biochim Biophys Acta. 1974 May 20;350(1):121-8. doi: 10.1016/0005-2744(74)90209-5.
7
Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.双硫仑和二乙基二硫代氨基甲酸盐在体内对乙醛脱氢酶的抑制机制。
Mol Pharmacol. 1971 May;7(3):301-7.
8
Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. 3. Sulfhydryl characteristics of the enzyme.二磷酸吡啶核苷酸连接的醛脱氢酶。3. 该酶的巯基特性。
Arch Biochem Biophys. 1967 Mar;119(1):253-63. doi: 10.1016/0003-9861(67)90452-3.
9
The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.双硫仑对绵羊肝脏醛脱氢酶的影响。
Biochem J. 1975 Nov;151(2):407-12. doi: 10.1042/bj1510407.

某些双硫仑类似物对绵羊肝脏醛脱氢酶的影响。

The effect of some analogues of disulfiram on the aldehyde dehydrogenases of sheep liver.

作者信息

Kitson T M

出版信息

Biochem J. 1976 May 1;155(2):445-8. doi: 10.1042/bj1550445.

DOI:10.1042/bj1550445
PMID:938491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1172852/
Abstract

The effect of some close structural analogues of disulfiram on the activity of the cytoplasmic and mitochondrial aldehyde dehydrogenases of sheep liver was studied. Several thiuram disulphides are equally potent inhibitors of the cytoplasmic enzyme, but in all cases the mitochondrial enzyme is much less strongly affected. Tetramethylthiuram monosulphide decreases the activity of the cytoplasmic enzyme in a process apparently involving a covalent interaction.

摘要

研究了双硫仑的一些结构类似物对绵羊肝脏细胞质和线粒体醛脱氢酶活性的影响。几种二硫化秋兰姆对细胞质酶具有同等效力的抑制作用，但在所有情况下，线粒体酶受影响的程度要小得多。一硫化四甲基秋兰姆在一个明显涉及共价相互作用的过程中降低了细胞质酶的活性。