2,2'-二硫代二吡啶激活醛脱氢酶，并保护该酶免受双硫仑的失活作用。
2,2'-Dithiodipyridine activates aldehyde dehydrogenase and protects the enzyme against inactivation by disulfiram.
作者信息
Kitson T M
出版信息
Biochem J. 1979 Dec 1;183(3):751-3. doi: 10.1042/bj1830751.
Abstract
Small concentrations of 2,2'-dithiodipyridine cause a rapid activation of sheep liver cytoplasmic aldehyde dehydrogenase in the presence of NAD+. Enzyme pre-modified by 2,2'-dithiodipyridine is largely protected against the potent inactivatory effect of disulfiram. 2,2'-Dithiobis-(5-nitropyridine) inactivates the enzyme. The implications of these results are discussed with reference to various possible classes of thiol group in aldehyde dehydrogenase.
摘要
在烟酰胺腺嘌呤二核苷酸（NAD⁺）存在的情况下，低浓度的2,2'-二硫代二吡啶会使绵羊肝脏细胞质醛脱氢酶迅速活化。经2,2'-二硫代二吡啶预先修饰的酶在很大程度上可免受双硫仑的强效失活作用影响。2,2'-二硫代双（5-硝基吡啶）会使该酶失活。本文参照醛脱氢酶中各种可能的巯基类别对这些结果的意义进行了讨论。
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引用本文的文献
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The inactivation of aldehyde dehydrogenase by disulfiram in the presence of glutathione.在谷胱甘肽存在的情况下，双硫仑使乙醛脱氢酶失活。
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本文引用的文献
1
Isolation and characterization of human liver aldehyde dehydrogenase.
J Biol Chem. 1968 Dec 25;243(24):6402-8.
2
Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity.马肝醛脱氢酶。II. 脱氢酶和酯酶活性的动力学及机制意义。
J Biol Chem. 1972 Jan 10;247(1):267-72.
3
Diphosphopyridine nucleotide-linked aldehyde dehydrogenase. 3. Sulfhydryl characteristics of the enzyme.二磷酸吡啶核苷酸连接的醛脱氢酶。3. 该酶的巯基特性。
Arch Biochem Biophys. 1967 Mar;119(1):253-63. doi: 10.1016/0003-9861(67)90452-3.
4
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Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
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Biochem J. 1978 Nov 1;175(2):753-6. doi: 10.1042/bj1750753.
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