Dimpfel W, Schombert L
Pro Science Private Research Clinic GmbH -med. Forschung und Entwicklung-, Kurt-Schumacher-Str. 9, Linden D-35440, Germany.
Eur J Med Res. 1997 Nov 28;2(11):491-6.
The central action of a plant extract containing hyperici herba flore extractum siccum has been investigated in freely moving rats during a 6 h exposure with two dosages. After frequency analysis of local field potentials electrical power changes of delta waves and alpha2 waves (less pronounced) could be observed within the frontal cortex and hippocampus. As these frequencies are changed predominantly in the presence of drugs acting at the cholinergic or dopaminergic transmitter system, a similar mode of action can be suspected for this plant extract. Despite the fact that statistical significance could only be observed during the fourth hour (p <0.1), the changes induced by the higher dose of the extract containing 1 mg of hypericine were very stable from the 2. to 4. hour after oral application. Classification of the parameters obtained by means of discriminant analysis revealed a trend into the direction of antidepressive EEG drug profiles. Results suggest that quantitative EEG analysis is a very sensitive methodology for the description of pharmacodynamic actions of plant extracts and data can be compared to the action of pure chemical entities.
在自由活动的大鼠中，使用两种剂量对含金丝桃草干燥花提取物的植物提取物进行了6小时的暴露实验，研究了其主要作用。在对局部场电位进行频率分析后，发现在额叶皮质和海马体中，δ波和α2波（不太明显）的电功率发生了变化。由于这些频率主要在作用于胆碱能或多巴胺能递质系统的药物存在时发生变化，因此可以怀疑这种植物提取物具有类似的作用模式。尽管仅在第4小时观察到统计学显著性（p <0.1），但口服含1毫克金丝桃素的较高剂量提取物所引起的变化在口服后第2至4小时非常稳定。通过判别分析获得的参数分类显示出向抗抑郁脑电图药物特征方向的趋势。结果表明，定量脑电图分析是描述植物提取物药效学作用的一种非常敏感的方法，并且可以将数据与纯化学实体的作用进行比较。
