Mandl T, Jacobsson L, Lilja B, Sundkvist G, Manthorpe R
Sjögren's Syndrome Research Centre, Malmö University Hospital, Sweden.
Scand J Rheumatol. 1997;26(5):401-6. doi: 10.3109/03009749709065710.
Autonomic nervous function was evaluated by deep breathing [expiration/inspiration (E/I) ratio] and tilt table tests [acceleration (AI) and brake indices (BI)] in 19 patients with primary Sjögren's syndrome (pSS) and in 56 age matched controls. The E/I-ratio and systolic blood pressure (at rest, 1, and 8 min after tilt) were found to be significantly reduced (p < 0.001, p < 0.05, p < 0.01, p < 0.01 respectively) in patients with pSS whereas neither AI, BI nor diastolic blood pressure did differ significantly between patients and controls (NS). The van Bijsterveld's score correlated negatively with the AI (r = -0.77, p< 0.001) as well as the BI (r = -0.60, p < 0.01). No correlations were found between the 3 autonomic nerve function parameters (E/I-ratio, AI, BI) and unstimulated whole sialometry or salivary gland scintigraphy. We conclude that autonomic disturbances, mainly affecting the parasympathetic nerves are associated with pSS.
通过深呼吸试验[呼气/吸气（E/I）比值]和倾斜试验[加速度指数（AI）和制动指数（BI）]对19例原发性干燥综合征（pSS）患者和56例年龄匹配的对照者的自主神经功能进行评估。结果发现，pSS患者的E/I比值和收缩压（静息时、倾斜后1分钟和8分钟）显著降低（分别为p < 0.001、p < 0.05、p < 0.01、p < 0.01），而患者与对照者之间的AI、BI和舒张压均无显著差异（无统计学意义）。范·比斯特费尔德评分与AI（r = -0.77，p < 0.001）以及BI（r = -0. , p < 0.01）呈负相关。未发现3种自主神经功能参数（E/I比值、AI、BI）与非刺激性全唾液流量测定或唾液腺闪烁扫描之间存在相关性。我们得出结论，自主神经功能紊乱主要影响副交感神经，与pSS有关。
