Mandl T, Bornmyr S V, Castenfors J, Jacobsson L T, Manthorpe R, Wollmer P
Sjögren's Syndrome Research Centre, Department of Rheumatology, Malmö University Hospital, Sweden.
J Rheumatol. 2001 Feb;28(2):296-301.
To investigate autonomic nervous system function in patients with primary Sjögren's syndrome (SS) and relate the findings to clinical variables.
Autonomic nervous system function was determined in 30 patients with primary SS using the finger skin blood flow test [vasoconstrictory (VAC) index], deep-breathing test [expiration/inspiration (E/I) ratio], and the tilt table (orthostatic) test [acceleration index (AI), brake index (BI), and orthostatic blood pressure]. The results were compared with age matched control materials (finger skin blood flow test, n = 80, and deep-breathing and tilt table tests, n = 56).
The VAC index was found to be significantly increased and the E/I ratio significantly decreased in patients compared to controls, indicating both a sympathetic and a parasympathetic dysfunction. Further, the patients, especially the anti-SSA and anti-SSB antibody seropositives, were found to have an abnormal blood pressure reaction to tilt compared to controls. No correlations were found between autonomic nerve function variables measured and the clinical ophthalmologic or the oral tests, performed at the time of diagnosis.
Patients with primary SS show signs of both sympathetic and parasympathetic dysfunction. Further, immunological mechanisms seem to influence blood pressure in patients with primary SS.
研究原发性干燥综合征（SS）患者的自主神经系统功能，并将研究结果与临床变量相关联。
采用手指皮肤血流试验[血管收缩（VAC）指数]、深呼吸试验[呼气/吸气（E/I）比值]和倾斜台（直立）试验[加速度指数（AI）、制动指数（BI）和直立血压]对30例原发性SS患者的自主神经系统功能进行测定。将结果与年龄匹配的对照材料进行比较（手指皮肤血流试验，n = 80；深呼吸和倾斜台试验，n = 56）。
与对照组相比，患者的VAC指数显著升高，E/I比值显著降低，表明交感神经和副交感神经均存在功能障碍。此外，与对照组相比，患者，尤其是抗SSA和抗SSB抗体血清阳性患者，对倾斜试验的血压反应异常。在诊断时进行的自主神经功能变量与临床眼科或口腔检查之间未发现相关性。
原发性SS患者表现出交感神经和副交感神经功能障碍的迹象。此外，免疫机制似乎影响原发性SS患者的血压。
