Mishima K, Takeshima T, Shimomura T, Okada H, Kitano A, Takahashi K, Nakashima K
Division of Neurology, Tottori University Faculty of Medicine, Yonago, Japan.
Headache. 1997 Oct;37(9):561-4. doi: 10.1046/j.1526-4610.1997.3709561.x.
Decreased serum and intracellular levels of magnesium have been reported in patients with migraine. It has been suggested that magnesium may play an important role in the attacks and pathogenesis of headaches. We measured ionized magnesium, cyclic AMP (adenosine monophosphate), and cyclic GMP (guanosine monophosphate) in platelets of patients with migraine, in patients with tension-type headache, and in healthy controls. The platelet level of ionized magnesium from patients with tension-type headache was significantly lower than the levels from the other two groups. The platelet level of cyclic AMP from patients with migraine was higher than those from the other groups. We found no significant differences in the platelet cyclic GMP levels among the three groups. It is suggested that reduced platelet ionized magnesium in patients with tension-type headache is related to abnormal platelet function, and that increased platelet cyclic AMP in patients with migraine is related to alteration of neurotransmitters in the platelet.
据报道，偏头痛患者血清和细胞内镁水平降低。有人认为镁可能在头痛发作和发病机制中起重要作用。我们测量了偏头痛患者、紧张型头痛患者和健康对照者血小板中的离子镁、环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）。紧张型头痛患者的血小板离子镁水平显著低于其他两组。偏头痛患者的血小板环磷酸腺苷水平高于其他组。我们发现三组之间血小板环磷酸鸟苷水平无显著差异。提示紧张型头痛患者血小板离子镁降低与血小板功能异常有关，偏头痛患者血小板环磷酸腺苷升高与血小板神经递质改变有关。
